6ZMK

Crystal structure of human GFAT-1 L405R

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	polymer	687	77820.0	1	UniProt (Q06210) Pfam (PF13522) Pfam (PF01380)	Homo sapiens (Human)	D-fructose-6-phosphate amidotransferase 1,Glutamine:fructose-6-phosphate amidotransferase 1,GFAT1,Hexosephosphate aminotransferase 1
2	B (B)	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	polymer	687	77740.0	1	UniProt (Q06210) Pfam (PF13522) Pfam (PF01380)	Homo sapiens (Human)	D-fructose-6-phosphate amidotransferase 1,Glutamine:fructose-6-phosphate amidotransferase 1,GFAT1,Hexosephosphate aminotransferase 1
3	C, E (A, B)	GLUCOSE-6-PHOSPHATE	non-polymer		260.1	2	Chemie (G6Q)
4	D (A)	GLUTAMIC ACID	non-polymer		147.1	1	Chemie (GLU)
5	F, G (A, B)	water	water		18.0	113	Chemie (HOH)

Sequence modifications

A: 1 - 681 (UniProt: Q06210)

PDB	External Database	Details
His 295	-	insertion
His 295	-	insertion
His 295	-	insertion
His 295	-	insertion
His 295	-	insertion
His 295	-	insertion
Arg 405	Leu 405	engineered mutation

B: 1 - 681 (UniProt: Q06210)

PDB	External Database	Details
His 293	-	insertion
His 293	-	insertion
His 293	-	insertion
His 293	-	insertion
His 293	-	insertion
His 293	-	insertion
Arg 405	Leu 405	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	155560.1
Non-Polymers*	Number of molecules	3
	Total formula weight	667.4
All*	Total formula weight	156227.5

*Water molecules are not included.