6ZMK
Crystal structure of human GFAT-1 L405R
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004360 | molecular_function | glutamine-fructose-6-phosphate transaminase (isomerizing) activity |
A | 0097367 | molecular_function | carbohydrate derivative binding |
A | 1901135 | biological_process | carbohydrate derivative metabolic process |
A | 1901137 | biological_process | carbohydrate derivative biosynthetic process |
B | 0004360 | molecular_function | glutamine-fructose-6-phosphate transaminase (isomerizing) activity |
B | 0097367 | molecular_function | carbohydrate derivative binding |
B | 1901135 | biological_process | carbohydrate derivative metabolic process |
B | 1901137 | biological_process | carbohydrate derivative biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue G6Q A 701 |
Chain | Residue |
A | CYS374 |
A | SER474 |
A | LYS558 |
A | GLU561 |
A | HOH823 |
A | HOH837 |
A | HOH842 |
A | HOH862 |
A | HOH867 |
B | HIS577 |
A | GLY375 |
A | THR376 |
A | SER377 |
A | SER421 |
A | GLN422 |
A | SER423 |
A | THR426 |
A | ALA473 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue GLU A 702 |
Chain | Residue |
A | CYS2 |
A | ARG95 |
A | TRP96 |
A | THR98 |
A | HIS99 |
A | HIS108 |
A | GLY124 |
A | ASP148 |
A | THR149 |
site_id | AC3 |
Number of Residues | 14 |
Details | binding site for residue G6Q B 701 |
Chain | Residue |
A | HIS577 |
B | GLY375 |
B | THR376 |
B | SER377 |
B | SER421 |
B | GLN422 |
B | SER423 |
B | THR426 |
B | ALA473 |
B | SER474 |
B | LYS558 |
B | GLU561 |
B | HOH804 |
B | HOH812 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: For GATase activity => ECO:0000250|UniProtKB:P14742 |
Chain | Residue | Details |
B | CYS2 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19059404, ECO:0007744|PDB:2V4M, ECO:0007744|PDB:2ZJ3, ECO:0007744|PDB:2ZJ4 |
Chain | Residue | Details |
B | THR376 | |
B | SER421 | |
B | THR426 | |
B | HIS577 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER103 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | SER261 |