6ZIZ
CRYSTAL STRUCTURE OF NRAS Q61R IN COMPLEX WITH GTP AND COMPOUND 18
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GTPase NRas | polymer | 173 | 19641.3 | 2 | UniProt (P01111) Pfam (PF00071) | Homo sapiens (Human) | Transforming protein N-Ras |
| 2 | C, F (A, B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one | non-polymer | 321.4 | 2 | Chemie (EZZ) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 172 (UniProt: P01111)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Arg 61 | Gln 61 | engineered mutation |
| Ser 118 | Cys 118 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 39282.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1737.7 | |
| All* | Total formula weight | 41020.3 |
