6ZIZ
CRYSTAL STRUCTURE OF NRAS Q61R IN COMPLEX WITH GTP AND COMPOUND 18
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0007265 | biological_process | Ras protein signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019003 | molecular_function | GDP binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045445 | biological_process | myoblast differentiation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070821 | cellular_component | tertiary granule membrane |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0000165 | biological_process | MAPK cascade |
| B | 0001938 | biological_process | positive regulation of endothelial cell proliferation |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007265 | biological_process | Ras protein signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019003 | molecular_function | GDP binding |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045445 | biological_process | myoblast differentiation |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070821 | cellular_component | tertiary granule membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue GTP A 201 |
| Chain | Residue |
| A | GLY12 |
| A | ASP30 |
| A | TYR32 |
| A | PRO34 |
| A | THR35 |
| A | GLY60 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | GLY13 |
| A | ALA146 |
| A | MG202 |
| A | HOH316 |
| A | HOH320 |
| A | HOH325 |
| A | HOH338 |
| A | HOH347 |
| A | HOH380 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | THR35 |
| A | GTP201 |
| A | HOH320 |
| A | HOH325 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue EZZ A 203 |
| Chain | Residue |
| A | LYS5 |
| A | VAL7 |
| A | GLU37 |
| A | ASP54 |
| A | LEU56 |
| A | ARG73 |
| A | THR74 |
| A | GLY75 |
| A | HOH379 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | binding site for residue GTP B 201 |
| Chain | Residue |
| B | GLY12 |
| B | GLY13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | ALA18 |
| B | PHE28 |
| B | VAL29 |
| B | ASP30 |
| B | TYR32 |
| B | PRO34 |
| B | THR35 |
| B | GLY60 |
| B | ASN116 |
| B | LYS117 |
| B | ASP119 |
| B | LEU120 |
| B | SER145 |
| B | ALA146 |
| B | MG202 |
| B | HOH317 |
| B | HOH320 |
| B | HOH339 |
| B | HOH341 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | SER17 |
| B | THR35 |
| B | GTP201 |
| B | HOH306 |
| B | HOH317 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue EZZ B 203 |
| Chain | Residue |
| B | LYS5 |
| B | VAL7 |
| B | GLU37 |
| B | ASP54 |
| B | LEU56 |
| B | TYR71 |
| B | THR74 |
| B | GLY75 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|Ref.25 |
| Chain | Residue | Details |
| A | GLY10 | |
| A | VAL29 | |
| A | ASN116 | |
| B | GLY10 | |
| B | VAL29 | |
| B | ASN116 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP57 | |
| B | ASP57 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by STK19 => ECO:0000269|PubMed:30712867 |
| Chain | Residue | Details |
| A | SER89 | |
| B | SER89 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486 |
| Chain | Residue | Details |
| A | THR35 | |
| B | THR35 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:30442762 |
| Chain | Residue | Details |
| A | LYS170 | |
| B | LYS170 |
