6ZEG
Structure of PP1-IRSp53 chimera [PP1(7-304) + linker (G/S)x9 + IRSp53(449-465)] bound to Phactr1 (516-580)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit,Brain-specific angiogenesis inhibitor 1-associated protein 2 | polymer | 338 | 37678.7 | 2 | UniProt (P62136) UniProt (Q9UQB8) Pfam (PF16891) Pfam (PF00149) In PDB | Homo sapiens (Human) | PP-1A,Protein BAP2,Fas ligand-associated factor 3,FLAF3,Insulin receptor substrate p53/p58,IRSp53/58,Insulin receptor substrate protein of 53 kDa,Insulin receptor substrate p53 |
| 2 | C, D | Phosphatase and actin regulator | polymer | 70 | 8257.3 | 2 | UniProt (Q4VY12) UniProt (by SIFTS) (Q9C0D0) In PDB | Homo sapiens (Human) | |
| 3 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 4 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 5 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | B | 3,6,9,12,15,18-HEXAOXAICOSANE | non-polymer | 294.4 | 1 | Chemie (16P) | |||
| 7 | water | water | 18.0 | 844 | Chemie (HOH) |
Sequence modifications
A, B: 7 - 304 (UniProt: P62136)
A, B: 323 - 339 (UniProt: Q9UQB8)
C, D: 516 - 580 (UniProt: Q4VY12)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | expression tag |
| His 3 | - | expression tag |
| Met 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Ser 305 | - | linker |
| Gly 306 | - | linker |
| Ser 307 | - | linker |
| Gly 308 | - | linker |
| Ser 309 | - | linker |
| Gly 310 | - | linker |
| Ser 311 | - | linker |
| Gly 312 | - | linker |
| Ser 313 | - | linker |
| Gly 314 | - | linker |
| Ser 315 | - | linker |
| Gly 316 | - | linker |
| Ser 317 | - | linker |
| Gly 318 | - | linker |
| Ser 319 | - | linker |
| Gly 320 | - | linker |
| Ser 321 | - | linker |
| Gly 322 | - | linker |
C, D: 516 - 580 (UniProt: Q4VY12)
| PDB | External Database | Details |
|---|---|---|
| Gly 511 | - | expression tag |
| Pro 512 | - | expression tag |
| Leu 513 | - | expression tag |
| Gly 514 | - | expression tag |
| Ser 515 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 91872.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 890.3 | |
| All* | Total formula weight | 92762.4 |
