6ZBZ
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dishevelled, dsh homolog 3 (Drosophila), isoform CRA_b | polymer | 95 | 10199.7 | 4 | UniProt (Q9UG07) Pfam (PF00595) UniProt (by SIFTS) (Q92997) | Homo sapiens (Human) | |
| 2 | E, F, H, K (A, B, C, D) | 2-[(3,4-dimethylphenyl)sulfonylamino]-5-fluoranyl-benzoic acid | non-polymer | 323.3 | 4 | Chemie (QE5) | |||
| 3 | G, I, J (B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 387 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 243 - 335 (UniProt: Q9UG07)
| PDB | External Database | Details |
|---|---|---|
| Ala 242 | - | expression tag |
| Ser 336 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 40798.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1479.6 | |
| All* | Total formula weight | 42278.3 |
