6Z86

human GTP cyclohydrolase I in complex with 7-deaza-GTP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	GTP cyclohydrolase 1	polymer	224	25324.9	20	UniProt (P30793) Pfam (PF01227)	Homo sapiens (Human)	GTP cyclohydrolase I,GTP-CH-I
2	AA, AB, CA, CB, EA... (D, Q, E, R, F...)	ZINC ION	non-polymer		65.4	20	Chemie (ZN)
3	BA, BB, DA, DB, FA... (D, Q, E, R, F...)	7-deaza-GTP	non-polymer		522.2	20	Chemie (QBQ)
4	AC, BC, IB, JB, KB... (S, T, A, B, C...)	water	water		18.0	636	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T: 41 - 250 (UniProt: P30793)

PDB	External Database	Details
Met 27	-	initiating methionine
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
Gly 34	-	expression tag
Ser 35	-	expression tag
Asp 36	-	expression tag
Asp 37	-	expression tag
Asp 38	-	expression tag
Asp 39	-	expression tag
Lys 40	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	20
	Total formula weight	506498.4
Non-Polymers*	Number of molecules	40
	Total formula weight	11752.0
All*	Total formula weight	518250.4

*Water molecules are not included.