6Z86

human GTP cyclohydrolase I in complex with 7-deaza-GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0046654	biological_process	tetrahydrofolate biosynthetic process
K	0003934	molecular_function	GTP cyclohydrolase I activity
K	0046654	biological_process	tetrahydrofolate biosynthetic process
L	0003934	molecular_function	GTP cyclohydrolase I activity
L	0046654	biological_process	tetrahydrofolate biosynthetic process
M	0003934	molecular_function	GTP cyclohydrolase I activity
M	0046654	biological_process	tetrahydrofolate biosynthetic process
N	0003934	molecular_function	GTP cyclohydrolase I activity
N	0046654	biological_process	tetrahydrofolate biosynthetic process
O	0003934	molecular_function	GTP cyclohydrolase I activity
O	0046654	biological_process	tetrahydrofolate biosynthetic process
P	0003934	molecular_function	GTP cyclohydrolase I activity
P	0046654	biological_process	tetrahydrofolate biosynthetic process
Q	0003934	molecular_function	GTP cyclohydrolase I activity
Q	0046654	biological_process	tetrahydrofolate biosynthetic process
R	0003934	molecular_function	GTP cyclohydrolase I activity
R	0046654	biological_process	tetrahydrofolate biosynthetic process
S	0003934	molecular_function	GTP cyclohydrolase I activity
S	0046654	biological_process	tetrahydrofolate biosynthetic process
T	0003934	molecular_function	GTP cyclohydrolase I activity
T	0046654	biological_process	tetrahydrofolate biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU128-HIS144

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site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER176-THR186

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	BINDING: BINDING => ECO:0000269|PubMed:11087827

Chain	Residue	Details
B	CYS141
B	HIS144
B	CYS212
C	CYS141
C	HIS144
C	CYS212
D	CYS141
D	HIS144
D	CYS212
E	CYS141
E	HIS144
E	CYS212
F	CYS141
F	HIS144
F	CYS212
G	CYS141
G	HIS144
G	CYS212
H	CYS141
H	HIS144
H	CYS212
I	CYS141
I	HIS144
I	CYS212
J	CYS141
J	HIS144
J	CYS212
K	CYS141
K	HIS144
K	CYS212
L	CYS141
L	HIS144
L	CYS212
M	CYS141
M	HIS144
M	CYS212
N	CYS141
N	HIS144
N	CYS212
O	CYS141
O	HIS144
O	CYS212
P	CYS141
P	HIS144
P	CYS212
Q	CYS141
Q	HIS144
Q	CYS212
R	CYS141
R	HIS144
R	CYS212
S	CYS141
S	HIS144
S	CYS212
T	CYS141
T	HIS144
T	CYS212
A	CYS141
A	HIS144
A	CYS212

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
C	SER60
D	SER60
E	SER60
F	SER60
G	SER60
H	SER60
I	SER60
J	SER60
K	SER60
L	SER60
M	SER60
N	SER60
O	SER60
P	SER60
Q	SER60
R	SER60
S	SER60
T	SER60
A	SER60
B	SER60

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17704208

Chain	Residue	Details
A	SER81
B	SER81
C	SER81
D	SER81
E	SER81
F	SER81
G	SER81
H	SER81
I	SER81
J	SER81
K	SER81
L	SER81
M	SER81
N	SER81
O	SER81
P	SER81
Q	SER81
R	SER81
S	SER81
T	SER81

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