6Z55
Crystal structure of CLK3 in complex with macrocycle ODS2004070
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dual specificity protein kinase CLK3 | polymer | 360 | 42318.4 | 2 | UniProt (P49761) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 3 |
| 2 | C, D, E, V, W (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 3 | AA, BA, CA, DA, EA... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 25 | Chemie (EDO) | |||
| 4 | JA, S, T (B, A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | KA, U (B, A) | 7,10-Dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxylic acid | non-polymer | 340.3 | 2 | Chemie (PQ5) | |||
| 6 | LA, MA (A, B) | water | water | 18.0 | 928 | Chemie (HOH) |
Sequence modifications
A, B: 127 - 484 (UniProt: P49761)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84636.8 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 2776.2 | |
| All* | Total formula weight | 87413.0 |
