Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 A 501 |
| Chain | Residue |
| A | HIS330 |
| B | THR332 |
| B | THR333 |
| A | THR332 |
| A | THR333 |
| A | HOH601 |
| A | HOH614 |
| A | HOH615 |
| A | HOH618 |
| A | HOH870 |
| B | HIS330 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 502 |
| Chain | Residue |
| A | ARG402 |
| A | LYS405 |
| A | HOH605 |
| A | HOH713 |
| A | HOH724 |
| A | HOH785 |
| A | HOH809 |
| B | HIS328 |
| B | GLU329 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 A 503 |
| Chain | Residue |
| A | ARG189 |
| A | ARG189 |
| A | LYS193 |
| A | LYS193 |
| A | TYR194 |
| A | TYR194 |
| A | HOH606 |
| A | HOH606 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | LEU412 |
| A | TRP414 |
| A | TRP414 |
| A | HOH617 |
| A | HOH617 |
| A | HOH699 |
| A | HOH699 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ARG451 |
| A | ALA458 |
| A | GLN459 |
| A | ARG460 |
| A | GLU465 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | PHE371 |
| A | THR372 |
| A | LEU373 |
| A | ASN427 |
| A | TYR434 |
| A | HOH746 |
| A | HOH876 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | HOH604 |
| B | ASN190 |
| B | GLY192 |
| B | ARG195 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | GLU348 |
| A | HOH662 |
| A | HOH732 |
| B | HIS330 |
| B | HIS331 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 509 |
| Chain | Residue |
| A | SER132 |
| A | SER135 |
| A | VAL145 |
| A | ASP150 |
| A | TRP151 |
| A | NA518 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 510 |
| Chain | Residue |
| A | GLN153 |
| A | GLU154 |
| B | HIS303 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 511 |
| Chain | Residue |
| A | ARG199 |
| A | ASN203 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 512 |
| Chain | Residue |
| A | GLY322 |
| A | ALA324 |
| A | HOH649 |
| A | HOH691 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 513 |
| Chain | Residue |
| A | GLU295 |
| A | PHE296 |
| A | HOH718 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 514 |
| Chain | Residue |
| A | ARG422 |
| A | HOH640 |
| B | ASP438 |
| B | SER439 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 515 |
| Chain | Residue |
| A | SER418 |
| A | SER419 |
| A | ASP420 |
| A | HOH765 |
| A | HOH788 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 516 |
| Chain | Residue |
| A | HIS330 |
| A | HIS331 |
| A | HOH613 |
| A | HOH918 |
| B | GLU348 |
| B | ARG402 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 517 |
| Chain | Residue |
| A | GLN278 |
| A | THR280 |
| A | THR325 |
| A | PHE326 |
| A | ASP327 |
| A | GLN353 |
| A | HOH695 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 518 |
| Chain | Residue |
| A | HOH860 |
| A | SER132 |
| A | SER135 |
| A | EDO509 |
| site_id | AE1 |
| Number of Residues | 11 |
| Details | binding site for residue PQ5 A 519 |
| Chain | Residue |
| A | ALA184 |
| A | LYS186 |
| A | PHE236 |
| A | GLU237 |
| A | LEU238 |
| A | LEU239 |
| A | ASP320 |
| A | HOH675 |
| A | HOH698 |
| A | HOH717 |
| A | HOH831 |
| site_id | AE2 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 B 501 |
| Chain | Residue |
| A | HOH807 |
| B | ARG402 |
| B | LYS403 |
| B | LYS405 |
| B | HOH602 |
| B | HOH614 |
| B | HOH706 |
| B | HOH763 |
| B | HOH766 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 502 |
| Chain | Residue |
| B | ARG189 |
| B | ARG189 |
| B | LYS193 |
| B | LYS193 |
| B | TYR194 |
| B | TYR194 |
| B | HOH833 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | GLY322 |
| B | ALA324 |
| B | HOH613 |
| B | HOH728 |
| B | HOH734 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | HIS328 |
| B | HOH640 |
| B | HOH750 |
| B | HOH790 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | ALA458 |
| B | GLN459 |
| B | ARG460 |
| B | GLU465 |
| B | HOH635 |
| B | HOH799 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | ASP224 |
| B | TRP225 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| A | ASP438 |
| B | ASP447 |
| B | ARG450 |
| B | ARG451 |
| B | GLU454 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | SER395 |
| B | HOH624 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | SER132 |
| B | VAL136 |
| B | VAL145 |
| B | ASP150 |
| B | TRP151 |
| B | HIS377 |
| site_id | AF2 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | ARG147 |
| B | LEU247 |
| B | PHE252 |
| B | GLU366 |
| B | GLY370 |
| B | PHE371 |
| B | THR372 |
| B | HOH601 |
| B | HOH772 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | LYS140 |
| B | ILE334 |
| B | ALA336 |
| B | HOH607 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 512 |
| Chain | Residue |
| B | ASP327 |
| B | GLN353 |
| B | HOH637 |
| B | HOH658 |
| B | HOH694 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 513 |
| Chain | Residue |
| B | PHE371 |
| B | LEU373 |
| B | TYR434 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 514 |
| Chain | Residue |
| B | ARG380 |
| B | TRP414 |
| B | ASP415 |
| B | SER418 |
| B | GLY421 |
| site_id | AF7 |
| Number of Residues | 8 |
| Details | binding site for residue NA B 515 |
| Chain | Residue |
| B | GLN278 |
| B | LEU279 |
| B | THR280 |
| B | THR325 |
| B | PHE326 |
| B | ASP327 |
| B | GLN353 |
| B | HOH694 |
| site_id | AF8 |
| Number of Residues | 11 |
| Details | binding site for residue PQ5 B 516 |
| Chain | Residue |
| B | VAL170 |
| B | ALA184 |
| B | LYS186 |
| B | PHE236 |
| B | GLU237 |
| B | LEU238 |
| B | LEU239 |
| B | ASP320 |
| B | HOH687 |
| B | HOH697 |
| B | HOH817 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGTFGKVVeCldhargksq.........VALK |
| Chain | Residue | Details |
| A | LEU162-LYS186 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LtHtDLKpeNILF |
| Chain | Residue | Details |
| A | LEU279-PHE291 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 632 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
