6Z52
Crystal structure of CLK3 in complex with macrocycle ODS2003136
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dual specificity protein kinase CLK3 | polymer | 360 | 42318.4 | 2 | UniProt (P49761) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 3 |
| 2 | C, D, E, F, G... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 3 | H, K, W, Y (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | AA, BA, CA, DA, EA... (B, A) | IODIDE ION | non-polymer | 126.9 | 14 | Chemie (IOD) | |||
| 5 | FA, Q (B, A) | 11,15-dimethyl-6-(4-methylpiperazin-1-yl)-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one | non-polymer | 478.6 | 2 | Chemie (Q8T) | |||
| 6 | GA, HA (A, B) | water | water | 18.0 | 575 | Chemie (HOH) |
Sequence modifications
A, B: 127 - 484 (UniProt: P49761)
| PDB | External Database | Details |
|---|---|---|
| Ser 125 | - | expression tag |
| Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84636.8 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 3496.3 | |
| All* | Total formula weight | 88133.2 |
