6Z3R
Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1 | polymer | 3411 | 379584.8 | 1 | UniProt (Q96Q15) Pfam (PF15785) Pfam (PF00454) Pfam (PF02260) | Homo sapiens (Human) | hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein |
| 2 | B (B) | Protein SMG8 | polymer | 991 | 109825.8 | 1 | UniProt (Q8ND04) Pfam (PF10220) | Homo sapiens (Human) | Amplified in breast cancer gene 2 protein,Protein smg-8 homolog |
| 3 | C (C) | Protein SMG9 | polymer | 520 | 57717.5 | 1 | UniProt (Q9H0W8) | Homo sapiens (Human) | Protein SMG-9 |
| 4 | D (E) | Regulator of nonsense transcripts 1 | polymer | 11 | 1236.3 | 1 | UniProt (Q92900) | Homo sapiens | ATP-dependent helicase RENT1,Nonsense mRNA reducing factor 1,NORF1,Up-frameshift suppressor 1 homolog,hUpf1 |
| 5 | E (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 6 | F (A) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 7 | G (C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 8 | H (C) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 147 - 244 (PDB: 6Z3R)
A: 248 - 1638 (UniProt: Q96Q15)
A: 1646 - 1717 (PDB: 6Z3R)
A: 1727 - 2056 (UniProt: Q96Q15)
A: 2068 - 2083 (PDB: 6Z3R)
A: 2088 - 3661 (UniProt: Q96Q15)
A: 248 - 1638 (UniProt: Q96Q15)
| PDB | External Database | Details |
|---|---|---|
| Arg 743 | Lys 743 | conflict |
| Lys 834 | Asn 834 | conflict |
| Ser 1209 | Ala 1209 | conflict |
A: 1727 - 2056 (UniProt: Q96Q15)
A: 2068 - 2083 (PDB: 6Z3R)
A: 2088 - 3661 (UniProt: Q96Q15)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 548364.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1697.7 | |
| All* | Total formula weight | 550062.0 |
