6Z3R
Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006406 | biological_process | mRNA export from nucleus |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0018105 | biological_process | peptidyl-serine phosphorylation |
| A | 0032204 | biological_process | regulation of telomere maintenance |
| A | 0033391 | cellular_component | chromatoid body |
| A | 0042162 | molecular_function | telomeric repeat DNA binding |
| A | 0046777 | biological_process | protein autophosphorylation |
| A | 0046854 | biological_process | phosphatidylinositol phosphate biosynthetic process |
| A | 0106310 | molecular_function | protein serine kinase activity |
| A | 2000622 | biological_process | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| B | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0045859 | biological_process | regulation of protein kinase activity |
| B | 2000622 | biological_process | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| C | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| C | 0001654 | biological_process | eye development |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0007420 | biological_process | brain development |
| C | 0007507 | biological_process | heart development |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 2000622 | biological_process | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue ANP A 3701 |
| Chain | Residue |
| A | THR2133 |
| A | LYS2134 |
| A | GLN2206 |
| A | TRP2207 |
| A | VAL2208 |
| A | ILE2353 |
| A | ASP2354 |
| A | ASN2356 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue IHP A 3702 |
| Chain | Residue |
| A | ARG1433 |
| A | LYS1434 |
| A | LYS1489 |
| A | LYS1523 |
| A | LYS1530 |
| A | LYS1617 |
| A | LYS1386 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue ATP C 601 |
| Chain | Residue |
| C | LEU212 |
| C | GLN213 |
| C | GLY214 |
| C | THR215 |
| C | GLY216 |
| C | LYS217 |
| C | SER218 |
| C | MET219 |
| C | GLN233 |
| C | ALA240 |
| C | GLN241 |
| C | LYS246 |
| C | THR253 |
| C | PRO272 |
| C | ASN372 |
| C | PRO432 |
| C | MET434 |
| C | MG602 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG C 602 |
| Chain | Residue |
| C | SER218 |
| C | THR253 |
| C | ATP601 |
Functional Information from PROSITE/UniProt
| site_id | PS00916 |
| Number of Residues | 21 |
| Details | PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. StAvmsMvgYIIgLgDRHldN |
| Chain | Residue | Details |
| A | SER2320-ASN2340 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Motif: {"description":"[ST]-Q motif 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"11544179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16452507","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
