6YK5

Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glutamate receptor 2	polymer	264	29278.7	1	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB	Rattus norvegicus (Norway Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	A	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
3	A	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
4	A	LITHIUM ION	non-polymer		6.9	1	Chemie (LI)
5	A	(S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]-pyrimidine-2,4(1H,3H)-dione	non-polymer		241.2	1	Chemie (PVK)
6	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7		water	water		18.0	446	Chemie (HOH)

Sequence modifications

A: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag

A: 120 - 264 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	linker
Thr 119	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29278.7
Non-Polymers*	Number of molecules	13
	Total formula weight	1228.3
All*	Total formula weight	30507.1

*Water molecules are not included.