6YK5

Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue GOL A 301

Chain	Residue
A	TRP71
A	VAL79
A	GLY118
A	PRO120
A	HOH453
A	HOH508
A	HOH523
A	HOH606
A	HOH649

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 302

Chain	Residue
A	ILE70
A	LYS116
A	LYS185
A	GLY186
A	HOH458
A	HOH524
A	HOH669

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 303

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	ASP248
A	HOH512

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 304

Chain	Residue
A	LYS117
A	GLU201
A	GLN202
A	CYS206
A	HOH412
A	HOH657

---

site_id	AC5
Number of Residues	8
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS60
A	ALA63
A	ASN72
A	SER140
A	HOH411
A	HOH435
A	HOH627
A	HOH632

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 A 306

Chain	Residue
A	MET18
A	MET19
A	ARG163
A	HOH547
A	HOH553
A	HOH585
A	HOH635

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 A 307

Chain	Residue
A	ARG64
A	LYS69

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 A 308

Chain	Residue
A	LYS116
A	HOH458
A	HOH468
A	HOH792

---

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 A 309

Chain	Residue
A	HIS46
A	LYS240
A	GLN244
A	HOH452
A	HOH771
A	HOH845

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 A 310

Chain	Residue
A	ILE152
A	ALA153
A	HOH648
A	HOH776

---

site_id	AD2
Number of Residues	4
Details	binding site for residue LI A 311

Chain	Residue
A	GLU97
A	ILE100
A	ASP101
A	HOH448

---

site_id	AD3
Number of Residues	16
Details	binding site for residue PVK A 312

Chain	Residue
A	GLU13
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	LEU192
A	GLU193
A	TYR220
A	HOH401
A	HOH496
A	HOH573

---

site_id	AD4
Number of Residues	1
Details	binding site for residue CL A 313

Chain	Residue
A	THR5

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---