6YAH

AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo peptides

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	AP-2 complex subunit alpha-2	polymer	628	70310.1	1	UniProt (P18484) Pfam (PF01602) In PDB	Rattus norvegicus (Norway rat)	100 kDa coated vesicle protein C,Adaptor protein complex AP-2 subunit alpha-2,Adaptor-related protein complex 2 subunit alpha-2,Alpha-adaptin C,Alpha2-adaptin,Clathrin assembly protein complex 2 alpha-C large chain,Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
2	B	AP-2 complex subunit beta	polymer	944	105619.3	1	UniProt (P63010) Pfam (PF01602) Pfam (PF02883) Pfam (PF09066) In PDB	Homo sapiens (Human)	AP105B,Adaptor protein complex AP-2 subunit beta,Adaptor-related protein complex 2 subunit beta,Beta-2-adaptin,Beta-adaptin,Clathrin assembly protein complex 2 beta large chain,Plasma membrane adaptor HA2/AP2 adaptin beta subunit
3	M	AP-2 complex subunit mu	polymer	446	51044.1	1	UniProt (P84092) Pfam (PF01217) Pfam (PF00928) In PDB	Rattus norvegicus (Norway rat)	AP-2 mu chain,Adaptor protein complex AP-2 subunit mu,Adaptor-related protein complex 2 subunit mu,Clathrin assembly protein complex 2 mu medium chain,Clathrin coat assembly protein AP50,Clathrin coat-associated protein AP50,Mu2-adaptin,Plasma membrane adaptor AP-2 50 kDa protein
4	S	AP-2 complex subunit sigma	polymer	142	17038.7	1	UniProt (P62743) Pfam (PF01217) In PDB	Mus musculus (House mouse)	Adaptor protein complex AP-2 subunit sigma,Adaptor-related protein complex 2 subunit sigma,Clathrin assembly protein 2 sigma small chain,Clathrin coat assembly protein AP17,Clathrin coat-associated protein AP17,Plasma membrane adaptor AP-2 17 kDa protein,Sigma-adaptin 3b,Sigma2-adaptin

Sequence modifications

A: 1 - 623 (UniProt: P18484)

PDB	External Database	Details
Asp 8	Glu 8	conflict
Glu 272	-	insertion
Gly 622	Pro 621	conflict
Gly 624	-	expression tag
Leu 625	-	expression tag
Val 626	-	expression tag
Pro 627	-	expression tag
Arg 628	-	expression tag

B: 1 - 937 (UniProt: P63010)

PDB	External Database	Details
Met -6	-	initiating methionine
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

M: 1 - 446 (UniProt: P84092)

PDB	External Database	Details
Met 237	-	insertion
Glu 238	-	insertion
Gln 239	-	insertion
Lys 240	-	insertion
Leu 241	-	insertion
Ile 242	-	insertion
Ser 243	-	insertion
Glu 244	-	insertion
Glu 245	-	insertion
Asp 246	-	insertion
Leu 247	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	244012.2
All*	Total formula weight	244012.2

*Water molecules are not included.