6YA7

Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase	polymer	358	40099.3	1	UniProt (O00311) Pfam (PF00069) In PDB	Homo sapiens (Human)	huCdc7,huCdc7,huCdc7
2	B	Protein DBF4 homolog A	polymer	144	16923.4	1	UniProt (Q9UBU7) Pfam (PF07535) In PDB	Homo sapiens (Human)	Activator of S phase kinase,Chiffon homolog A,DBF4-type zinc finger-containing protein 1
3	C	DNA replication licensing factor MCM2	polymer	15	1797.9	1	UniProt (P49736) In PDB	Homo sapiens	Minichromosome maintenance protein 2 homolog,Nuclear protein BM28
4	A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
6		water	water		18.0	366	Chemie (HOH)

Sequence modifications

A: 37 - 345 (UniProt: O00311)
A: 346 - 466 (UniProt: O00311)
A: 534 - 574 (UniProt: O00311)

PDB	External Database	Details
Gly 467	-	linker
Ala 468	-	linker
Gly 469	-	linker
Ala 470	-	linker
Gly 471	-	linker

B: 210 - 350 (UniProt: Q9UBU7)

PDB	External Database	Details
Gly 207	-	expression tag
Pro 208	-	expression tag
Gly 209	-	expression tag

C: 33 - 47 (UniProt: P49736)

PDB	External Database	Details
7o5 40	Ser 40	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	58820.6
Non-Polymers*	Number of molecules	5
	Total formula weight	688.8
All*	Total formula weight	59509.4

*Water molecules are not included.