6XQN
Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, MCU, EMRE) in low Ca2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, F (E, G, H) | Protein EMRE homolog, mitochondrial-like Protein | polymer | 70 | 7372.2 | 3 | UniProt (D6X268) Pfam (PF10161) | Tribolium castaneum (Red flour beetle) | EMRE |
| 2 | B, C, E, G (A, B, C, D) | Calcium uniporter protein | polymer | 203 | 23634.1 | 4 | UniProt (D6WIX5) Pfam (PF04678) | Tribolium castaneum (Red flour beetle) | MCU |
| 3 | H (I) | Calcium uptake protein 1, mitochondrial | polymer | 394 | 45422.9 | 1 | UniProt (Q9BPX6) Pfam (PF13202) | Homo sapiens (Human) | Atopy-related autoantigen CALC,ara CALC,Calcium-binding atopy-related autoantigen 1, MICU1 |
| 4 | I (J) | Calcium uptake protein 2, mitochondrial | polymer | 383 | 44980.6 | 1 | UniProt (Q8IYU8) | Homo sapiens (Human) | EF-hand domain-containing family member A1, MICU2 |
| 5 | J (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence modifications
E, G, H: 47 - 108 (UniProt: D6X268)
A, B, C, D: 166 - 351 (UniProt: D6WIX5)
I: 94 - 476 (UniProt: Q9BPX6)
| PDB | External Database | Details |
|---|---|---|
| Gly 39 | - | expression tag |
| Pro 40 | - | expression tag |
| Thr 41 | - | expression tag |
| Ala 42 | - | expression tag |
| Ala 43 | - | expression tag |
| Ala 44 | - | expression tag |
| Leu 45 | - | expression tag |
| Glu 46 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 159 | - | expression tag |
| Pro 160 | - | expression tag |
| Thr 161 | - | expression tag |
| Ala 162 | - | expression tag |
| Ala 163 | - | expression tag |
| Ala 164 | - | expression tag |
| Leu 165 | - | expression tag |
| Gly 352 | - | expression tag |
| Gly 353 | - | expression tag |
| Trp 354 | - | expression tag |
| Ser 355 | - | expression tag |
| His 356 | - | expression tag |
| Pro 357 | - | expression tag |
| Gln 358 | - | expression tag |
| Phe 359 | - | expression tag |
| Glu 360 | - | expression tag |
| Lys 361 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 86 | - | expression tag |
| Pro 87 | - | expression tag |
| Thr 88 | - | expression tag |
| Ala 89 | - | expression tag |
| Ala 90 | - | expression tag |
| Ala 91 | - | expression tag |
| Leu 92 | - | expression tag |
| Glu 93 | - | expression tag |
| Ser 477 | - | expression tag |
| Asn 478 | - | expression tag |
| Trp 479 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 207056.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 40.1 | |
| All* | Total formula weight | 207096.5 |
