6XQN

Structure of a mitochondrial calcium uniporter holocomplex (MICU1, MICU2, MCU, EMRE) in low Ca2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0051560	biological_process	mitochondrial calcium ion homeostasis
B	0051560	biological_process	mitochondrial calcium ion homeostasis
C	0051560	biological_process	mitochondrial calcium ion homeostasis
D	0051560	biological_process	mitochondrial calcium ion homeostasis
E	0036444	biological_process	calcium import into the mitochondrion
E	0051560	biological_process	mitochondrial calcium ion homeostasis
E	1990246	cellular_component	uniplex complex
G	0036444	biological_process	calcium import into the mitochondrion
G	0051560	biological_process	mitochondrial calcium ion homeostasis
G	1990246	cellular_component	uniplex complex
H	0036444	biological_process	calcium import into the mitochondrion
H	0051560	biological_process	mitochondrial calcium ion homeostasis
H	1990246	cellular_component	uniplex complex
I	0005509	molecular_function	calcium ion binding
I	0006851	biological_process	mitochondrial calcium ion transmembrane transport
J	0005509	molecular_function	calcium ion binding
J	0006851	biological_process	mitochondrial calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CA B 401

Chain	Residue
A	GLU264
B	GLU264
C	GLU264
D	GLU264

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Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DLNGDGEVDmeEF

Chain	Residue	Details
I	ASP231-PHE243
I	ASP421-PHE433

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32667285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32841658","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X4S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	164
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32667285","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	32
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	136
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	40
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"32667285","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32667285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32841658","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6X4S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6XQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Region: {"description":"K/R-ring","evidences":[{"source":"PubMed","id":"32494073","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24514027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VCX5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	35
Details	Domain: {"description":"EF-hand 3; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	35
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32790952","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31397067","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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