6X40
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Gamma-aminobutyric acid receptor subunit beta-2 | polymer | 364 | 41810.1 | 2 | UniProt (P47870) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit beta-2 |
| 2 | B, D (B, D) | Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 358 | 41061.2 | 2 | UniProt (P14867) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit alpha-1 |
| 3 | E (E) | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 417 | 47673.1 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | GABA(A) receptor subunit gamma-2 |
| 4 | F, H (I, L) | Kappa Fab Light Chain | polymer | 213 | 23505.9 | 2 | Mus musculus | ||
| 5 | G, I (J, K) | IgG2b Fab Heavy Chain | polymer | 454 | 49811.0 | 2 | Mus musculus | ||
| 6 | J, L, M (F, H, M) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 7 | K (G) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
| 8 | N (N) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 9 | O, Q (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 10 | P, R (A, C) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) | |||
| 11 | S (D) | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione | non-polymer | 292.3 | 1 | Chemie (RI5) |
Sequence modifications
A, C: 1 - 307 (UniProt: P47870)
A, C: 316 - 341 (UniProt: P47870)
A, C: 342 - 364 (PDB: 6X40)
B, D: 1 - 312 (UniProt: P14867)
B, D: 320 - 358 (UniProt: P14867)
E: -36 - 2 (PDB: 6X40)
E: 3 - 322 (UniProt: P18507)
E: 330 - 380 (PDB: 6X40)
A, C: 316 - 341 (UniProt: P47870)
| PDB | External Database | Details |
|---|---|---|
| Ser 308 | - | linker |
| Gln 309 | - | linker |
| Pro 310 | - | linker |
| Ala 311 | - | linker |
| Arg 312 | - | linker |
| Ala 313 | - | linker |
| Ala 314 | - | linker |
| Ala 315 | - | linker |
B, D: 1 - 312 (UniProt: P14867)
B, D: 320 - 358 (UniProt: P14867)
| PDB | External Database | Details |
|---|---|---|
| Ser 313 | - | linker |
| Gln 314 | - | linker |
| Pro 315 | - | linker |
| Ala 316 | - | linker |
| Arg 317 | - | linker |
| Ala 318 | - | linker |
| Ala 319 | - | linker |
E: 3 - 322 (UniProt: P18507)
| PDB | External Database | Details |
|---|---|---|
| Ser 323 | - | linker |
| Gln 324 | - | linker |
| Pro 325 | - | linker |
| Ala 326 | - | linker |
| Arg 327 | - | linker |
| Ala 328 | - | linker |
| Ala 329 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 360049.7 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 3905.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 940.9 | |
| All* | Total formula weight | 364896.2 |
