6X40
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0004890 | molecular_function | GABA-A receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0004890 | molecular_function | GABA-A receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0004890 | molecular_function | GABA-A receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0004890 | molecular_function | GABA-A receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0004890 | molecular_function | GABA-A receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0006821 | biological_process | chloride transport |
E | 0007214 | biological_process | gamma-aminobutyric acid signaling pathway |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
site_id | PS00236 |
Number of Residues | 15 |
Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpMhLedFPmDahaC |
Chain | Residue | Details |
B | CYS139-CYS153 | |
A | CYS136-CYS150 | |
E | CYS151-CYS165 |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
Chain | Residue | Details |
I | TYR191-HIS197 | |
J | PHE430-HIS436 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 248 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
E | ALA11-LEU246 | |
E | ARG284-ALA295 | |
E | LEU355-LEU357 | |
D | GLN1-PHE226 | |
D | ASN275-THR284 | |
D | TYR344-GLN358 |
site_id | SWS_FT_FI2 |
Number of Residues | 83 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53 |
Chain | Residue | Details |
E | THR237-ILE257 | |
E | ALA264-ALA283 | |
E | MET296-PHE320 | |
E | TYR334-TYR354 | |
D | VAL227-LEU247 | |
D | PRO253-ARG274 | |
D | ALA285-THR306 | |
D | LEU324-THR343 |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
E | ASN258-PRO263 | |
D | ASN248-VAL252 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
E | ASN13 | |
E | ASN90 | |
A | THR202 | |
C | TYR97 | |
C | SER156 | |
C | THR202 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6I53 |
Chain | Residue | Details |
E | ASN208 | |
D | THR130 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30266951 |
Chain | Residue | Details |
B | TRP246 | |
D | TRP246 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
B | ASN11 | |
D | ASN11 | |
C | ASN80 | |
C | ASN149 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6D6U, ECO:0007744|PDB:6I53 |
Chain | Residue | Details |
B | ASN111 | |
D | ASN111 |