6X40
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin
Summary for 6X40
Entry DOI | 10.2210/pdb6x40/pdb |
EMDB information | 22038 |
Descriptor | Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, ... (11 entities in total) |
Functional Keywords | ion channel, cys-loop receptor, pentametic ligand gated channel, gabaa receptor, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 9 |
Total formula weight | 364896.17 |
Authors | Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh, R.M.,Lindahl, E.,Hibbs, R.E. (deposition date: 2020-05-21, release date: 2020-09-09, Last modification date: 2023-11-15) |
Primary citation | Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh Jr., R.M.,Lindahl, E.,Hibbs, R.E. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585:303-308, 2020 Cited by PubMed: 32879488DOI: 10.1038/s41586-020-2654-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.86 Å) |
Structure validation
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