6WZW
Ash1L SET domain in complex with AS-85
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histone-lysine N-methyltransferase ASH1L | polymer | 226 | 26016.5 | 1 | UniProt (Q9NR48) Pfam (PF17907) Pfam (PF00856) In PDB | Homo sapiens (Human) | ASH1-like protein,huASH1,Absent small and homeotic disks protein 1 homolog,Lysine N-methyltransferase 2H |
| 2 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 3 | A | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) | |||
| 4 | A | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 5 | A | N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide | non-polymer | 579.7 | 1 | Chemie (UG7) | |||
| 6 | water | water | 18.0 | 256 | Chemie (HOH) |
Sequence modifications
A: 2069 - 2288 (UniProt: Q9NR48)
| PDB | External Database | Details |
|---|---|---|
| Gly 2063 | - | expression tag |
| Ala 2064 | - | expression tag |
| Met 2065 | - | expression tag |
| Ala 2066 | - | expression tag |
| Gly 2067 | - | expression tag |
| Ser 2068 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26016.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1412.6 | |
| All* | Total formula weight | 27429.1 |
