6WWZ
Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
2 | C | C-C motif chemokine 20 | polymer | 70 | 8043.6 | 1 | UniProt (P78556) Pfam (PF00048) In PDB | Homo sapiens (Human) | Beta-chemokine exodus-1,CC chemokine LARC,Liver and activation-regulated chemokine,Macrophage inflammatory protein 3 alpha,MIP-3-alpha,Small-inducible cytokine A20 |
3 | Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | Pfam (PF00631) UniProt (by SIFTS) (P59768) In PDB | Rattus norvegicus (Norway rat) | |
4 | A | Guanine nucleotide-binding protein G(o) subunit alpha,Guanine nucleotide-binding protein G(o) subunit alpha | polymer | 250 | 28195.9 | 1 | UniProt (P09471) Pfam (PF00503) In PDB | Homo sapiens (Human) | |
5 | S | scFv16 | polymer | 287 | 30895.5 | 1 | Mus musculus (Mouse) | ||
6 | R | C-C chemokine receptor type 6,C-C chemokine receptor type 6 | polymer | 529 | 60064.6 | 1 | UniProt (P51684) Pfam (PF07361) Pfam (PF00001) UniProt (by SIFTS) (P0ABE7) In PDB | Homo sapiens (Human) | CCR-6,Chemokine receptor-like 3,CKR-L3,DRY6,G-protein coupled receptor 29,GPR-CY4,GPRCY4,LARC receptor |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
A: 4 - 173 (UniProt: P09471)
A: 182 - 354 (UniProt: P09471)
R: -144 - 1 (PDB: 6WWZ)
R: 2 - 374 (UniProt: P51684)
PDB | External Database | Details |
---|---|---|
Met -10 | - | initiating methionine |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Gly -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Glu -3 | - | expression tag |
Asn -2 | - | expression tag |
Leu -1 | - | expression tag |
Tyr 0 | - | expression tag |
Phe 1 | - | expression tag |
Gln 2 | - | expression tag |
Gly 3 | - | expression tag |
Asp 42 | Gly 42 | conflict |
Asn 43 | Glu 43 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 174 | - | linker |
Gly 175 | - | linker |
Ser 176 | - | linker |
Gly 177 | - | linker |
Gly 178 | - | linker |
Ser 179 | - | linker |
Gly 180 | - | linker |
Gly 181 | - | linker |
Asp 227 | Ala 227 | conflict |
Asp 230 | Gly 230 | conflict |
Asp 250 | Leu 250 | conflict |
Ala 332 | Ile 332 | conflict |
Ile 335 | Val 335 | conflict |
R: 2 - 374 (UniProt: P51684)
PDB | External Database | Details |
---|---|---|
His 375 | - | expression tag |
His 376 | - | expression tag |
His 377 | - | expression tag |
His 378 | - | expression tag |
His 379 | - | expression tag |
His 380 | - | expression tag |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 173507.7 | |
All* | Total formula weight | 173507.7 |