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6WWZ

Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008283biological_processcell population proliferation
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071456biological_processcellular response to hypoxia
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006935biological_processchemotaxis
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007165biological_processsignal transduction
C0007267biological_processcell-cell signaling
C0008009molecular_functionchemokine activity
C0016477biological_processcell migration
C0019722biological_processcalcium-mediated signaling
C0030335biological_processpositive regulation of cell migration
C0031731molecular_functionCCR6 chemokine receptor binding
C0042379molecular_functionchemokine receptor binding
C0042742biological_processdefense response to bacterium
C0048020molecular_functionCCR chemokine receptor binding
C0060326biological_processcell chemotaxis
C0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
C0070098biological_processchemokine-mediated signaling pathway
C0072678biological_processT cell migration
C0072679biological_processthymocyte migration
C2000406biological_processpositive regulation of T cell migration
R0002407biological_processdendritic cell chemotaxis
R0002523biological_processleukocyte migration involved in inflammatory response
R0004930molecular_functionG protein-coupled receptor activity
R0004950molecular_functionchemokine receptor activity
R0005506molecular_functioniron ion binding
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0006935biological_processchemotaxis
R0006955biological_processimmune response
R0006959biological_processhumoral immune response
R0006968biological_processcellular defense response
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0009055molecular_functionelectron transfer activity
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0016020cellular_componentmembrane
R0016493molecular_functionC-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0019957molecular_functionC-C chemokine binding
R0020037molecular_functionheme binding
R0022900biological_processelectron transport chain
R0036126cellular_componentsperm flagellum
R0038023molecular_functionsignaling receptor activity
R0042597cellular_componentperiplasmic space
R0048290biological_processisotype switching to IgA isotypes
R0060326biological_processcell chemotaxis
R0060474biological_processpositive regulation of flagellated sperm motility involved in capacitation
R0070098biological_processchemokine-mediated signaling pathway
R0072676biological_processlymphocyte migration
R0072678biological_processT cell migration
R0072679biological_processthymocyte migration
R0097225cellular_componentsperm midpiece
R0097228cellular_componentsperm principal piece
R0097524cellular_componentsperm plasma membrane
R1904155biological_processDN2 thymocyte differentiation
R1904156biological_processDN3 thymocyte differentiation
R2000404biological_processregulation of T cell migration
R2000510biological_processpositive regulation of dendritic cell chemotaxis
Y0005515molecular_functionprotein binding
Y0005834cellular_componentheterotrimeric G-protein complex
Y0005886cellular_componentplasma membrane
Y0007165biological_processsignal transduction
Y0007186biological_processG protein-coupled receptor signaling pathway
Y0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
Y0016020cellular_componentmembrane
Y0031681molecular_functionG-protein beta-subunit binding
Y0048144biological_processfibroblast proliferation
Y0070062cellular_componentextracellular exosome
Y0071380biological_processcellular response to prostaglandin E stimulus
Y0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. CGMlLLTCISMDRYIaI
ChainResidueDetails
RCYS131-ILE147

site_idPS00472
Number of Residues44
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLgytdri..LhpkfIvgFtrqlanegCdin.AIIFhtkkklsv.CA
ChainResidueDetails
CCYS6-ALA49

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
YALA2
ASER47
ATHR182
AASP201
AASN270
AALA326

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
YCYS68
RASP142-ARG159
RLYS239-ARG254
RLYS322-MET374

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
YCYS68

site_idSWS_FT_FI4
Number of Residues67
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
RSER105-LYS119
RSER181-LYS211
RASN280-VAL303

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RLEU120-MET141

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RTHR160-SER180

site_idSWS_FT_FI7
Number of Residues26
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RLEU212-VAL238

site_idSWS_FT_FI8
Number of Residues24
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RVAL255-ALA279

site_idSWS_FT_FI9
Number of Residues17
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RLEU304-GLN321

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN7
RASN23

site_idSWS_FT_FI11
Number of Residues2
DetailsBINDING: axial binding residue
ChainResidueDetails
RTRP-107
RILE-12

222926

PDB entries from 2024-07-24

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