6WWZ
Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0001917 | cellular_component | photoreceptor inner segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007200 | biological_process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| B | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0010659 | biological_process | cardiac muscle cell apoptotic process |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0030425 | cellular_component | dendrite |
| B | 0030507 | molecular_function | spectrin binding |
| B | 0042622 | cellular_component | photoreceptor outer segment membrane |
| B | 0044297 | cellular_component | cell body |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045202 | cellular_component | synapse |
| B | 0047391 | molecular_function | alkylglycerophosphoethanolamine phosphodiesterase activity |
| B | 0050909 | biological_process | sensory perception of taste |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0071456 | biological_process | cellular response to hypoxia |
| C | 0005125 | molecular_function | cytokine activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0006935 | biological_process | chemotaxis |
| C | 0006954 | biological_process | inflammatory response |
| C | 0006955 | biological_process | immune response |
| C | 0007165 | biological_process | signal transduction |
| C | 0007267 | biological_process | cell-cell signaling |
| C | 0008009 | molecular_function | chemokine activity |
| C | 0019722 | biological_process | calcium-mediated signaling |
| C | 0031731 | molecular_function | CCR6 chemokine receptor binding |
| C | 0042742 | biological_process | defense response to bacterium |
| C | 0060326 | biological_process | cell chemotaxis |
| C | 0072678 | biological_process | T cell migration |
| C | 0072679 | biological_process | thymocyte migration |
| C | 2000406 | biological_process | positive regulation of T cell migration |
| R | 0002407 | biological_process | dendritic cell chemotaxis |
| R | 0002523 | biological_process | leukocyte migration involved in inflammatory response |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004950 | molecular_function | chemokine receptor activity |
| R | 0005506 | molecular_function | iron ion binding |
| R | 0005515 | molecular_function | protein binding |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0006935 | biological_process | chemotaxis |
| R | 0006955 | biological_process | immune response |
| R | 0006959 | biological_process | humoral immune response |
| R | 0006968 | biological_process | cellular defense response |
| R | 0007165 | biological_process | signal transduction |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| R | 0009055 | molecular_function | electron transfer activity |
| R | 0009897 | cellular_component | external side of plasma membrane |
| R | 0009986 | cellular_component | cell surface |
| R | 0016020 | cellular_component | membrane |
| R | 0016493 | molecular_function | C-C chemokine receptor activity |
| R | 0019722 | biological_process | calcium-mediated signaling |
| R | 0019957 | molecular_function | C-C chemokine binding |
| R | 0020037 | molecular_function | heme binding |
| R | 0022900 | biological_process | electron transport chain |
| R | 0036126 | cellular_component | sperm flagellum |
| R | 0038023 | molecular_function | signaling receptor activity |
| R | 0042597 | cellular_component | periplasmic space |
| R | 0048290 | biological_process | isotype switching to IgA isotypes |
| R | 0060326 | biological_process | cell chemotaxis |
| R | 0060474 | biological_process | positive regulation of flagellated sperm motility involved in capacitation |
| R | 0070098 | biological_process | chemokine-mediated signaling pathway |
| R | 0072676 | biological_process | lymphocyte migration |
| R | 0072678 | biological_process | T cell migration |
| R | 0072679 | biological_process | thymocyte migration |
| R | 0097225 | cellular_component | sperm midpiece |
| R | 0097228 | cellular_component | sperm principal piece |
| R | 0097524 | cellular_component | sperm plasma membrane |
| R | 1904155 | biological_process | DN2 thymocyte differentiation |
| R | 1904156 | biological_process | DN3 thymocyte differentiation |
| R | 2000404 | biological_process | regulation of T cell migration |
| R | 2000510 | biological_process | positive regulation of dendritic cell chemotaxis |
| Y | 0005515 | molecular_function | protein binding |
| Y | 0005834 | cellular_component | heterotrimeric G-protein complex |
| Y | 0005886 | cellular_component | plasma membrane |
| Y | 0007165 | biological_process | signal transduction |
| Y | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| Y | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| Y | 0016020 | cellular_component | membrane |
| Y | 0031681 | molecular_function | G-protein beta-subunit binding |
| Y | 0045202 | cellular_component | synapse |
| Y | 0048144 | biological_process | fibroblast proliferation |
| Y | 0070062 | cellular_component | extracellular exosome |
| Y | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| Y | 0071870 | biological_process | cellular response to catecholamine stimulus |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. CGMlLLTCISMDRYIaI |
| Chain | Residue | Details |
| R | CYS131-ILE147 |
| site_id | PS00472 |
| Number of Residues | 44 |
| Details | SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCLgytdri..LhpkfIvgFtrqlanegCdin.AIIFhtkkklsv.CA |
| Chain | Residue | Details |
| C | CYS6-ALA49 |
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 13 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 9 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 5 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P18872","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"5-glutamyl histamine","evidences":[{"source":"UniProtKB","id":"P18872","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylcysteine; by pertussis toxin","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"33408414","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 40 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 67 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 17 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
