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6WWA

Crystal structure of human SHLD2-SHLD3-REV7 complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, D, C, B)
Mitotic spindle assembly checkpoint protein MAD2Bpolymer21124323.34UniProt (Q9UI95)
Pfam (PF02301)
Homo sapiens (Human)Mitotic arrest deficient 2-like protein 2,MAD2-like protein 2,REV7 homolog,hREV7
2E, F
(Y, X)
Shieldin complex subunit 2,Shieldin complex subunit 3 chimerapolymer9910678.12UniProt (Q86V20)
UniProt (Q6ZNX1)
Homo sapiens (Human)Protein FAM35A,RINN1-REV7-interacting novel NHEJ regulator 2,Shield complex subunit 2,REV7-interacting novel NHEJ regulator 1,Shield complex subunit 3
Sequence modifications
A, D, C, B: 2 - 211 (UniProt: Q9UI95)
PDBExternal DatabaseDetails
Ser 1-expression tag
Y, X: 2 - 16 (UniProt: Q86V20)
PDBExternal DatabaseDetails
Met 1-initiating methionine
Gly 17-linker
Ser 18-linker
Gly 19-linker
Ser 20-linker
Gly 21-linker
Ser 22-linker
Gly 23-linker
Ser 24-linker
Gly 25-linker
Ser 26-linker
Gly 27-linker
Ser 28-linker
Gly 29-linker
Ser 30-linker
Gly 31-linker
Ser 32-linker
Y, X: 33 - 89 (UniProt: Q6ZNX1)
PDBExternal DatabaseDetails
Ala 90-expression tag
Ser 91-expression tag
Arg 92-expression tag
Glu 93-expression tag
Glu 94-expression tag
Ile 95-expression tag
Met 96-expression tag
Ala 97-expression tag
Thr 98-expression tag
Leu 99-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight118649.7
All*Total formula weight118649.7
*Water molecules are not included.

229183

PDB entries from 2024-12-18

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