6WVW
Crystal structure of the R59P-SNAP25 containing SNARE complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Vesicle-associated membrane protein 2 | polymer | 63 | 7231.1 | 2 | UniProt (P63045) Pfam (PF00957) | Rattus norvegicus (Rat) | VAMP-2,Synaptobrevin-2 |
| 2 | B, F (B, F) | Syntaxin-1A | polymer | 66 | 7706.8 | 2 | UniProt (P32851) Pfam (PF05739) | Rattus norvegicus (Rat) | Neuron-specific antigen HPC-1,Synaptotagmin-associated 35 kDa protein,P35A |
| 3 | C, G (C, G) | Synaptosomal-associated protein 25 | polymer | 74 | 8567.5 | 2 | UniProt (P60881) | Rattus norvegicus (Rat) | SNAP-25,Super protein,SUP,Synaptosomal-associated 25 kDa protein |
| 4 | D, H (D, H) | Synaptosomal-associated protein 25 | polymer | 64 | 7340.2 | 2 | UniProt (P60881) | Rattus norvegicus (Rat) | SNAP-25,Super protein,SUP,Synaptosomal-associated 25 kDa protein |
| 5 | I, K, M, N (B, C, E, F) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | J, L (C, E) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 2 | Chemie (MPD) | |||
| 7 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 264 | Chemie (HOH) |
Sequence modifications
A, E: 28 - 89 (UniProt: P63045)
C, G: 10 - 83 (UniProt: P60881)
| PDB | External Database | Details |
|---|---|---|
| Gly 27 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro 59 | Arg 59 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 61691.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 396.7 | |
| All* | Total formula weight | 62087.7 |
