6WVW
Crystal structure of the R59P-SNAP25 containing SNARE complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0016192 | biological_process | vesicle-mediated transport |
| B | 0005484 | molecular_function | SNAP receptor activity |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016192 | biological_process | vesicle-mediated transport |
| C | 0000149 | molecular_function | SNARE binding |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0017075 | molecular_function | syntaxin-1 binding |
| E | 0016020 | cellular_component | membrane |
| E | 0016192 | biological_process | vesicle-mediated transport |
| F | 0005484 | molecular_function | SNAP receptor activity |
| F | 0006886 | biological_process | intracellular protein transport |
| F | 0016020 | cellular_component | membrane |
| F | 0016192 | biological_process | vesicle-mediated transport |
| G | 0000149 | molecular_function | SNARE binding |
| G | 0005249 | molecular_function | voltage-gated potassium channel activity |
| G | 0017075 | molecular_function | syntaxin-1 binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue CA B 301 |
| Chain | Residue |
| B | GLU238 |
| B | HOH401 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MPD C 201 |
| Chain | Residue |
| C | ARG30 |
| C | LEU33 |
| C | GLN34 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 202 |
| Chain | Residue |
| D | HOH343 |
| C | GLY54 |
| C | ASP58 |
| C | HOH314 |
| D | GLN177 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MPD E 101 |
| Chain | Residue |
| E | LYS83 |
| E | HOH202 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CA E 102 |
| Chain | Residue |
| D | HOH323 |
| E | ASP65 |
| E | HOH210 |
| E | HOH227 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CA F 301 |
| Chain | Residue |
| F | GLU238 |
| F | HOH403 |
| F | HOH427 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)","evidences":[{"source":"PubMed","id":"8505288","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)","evidences":[{"source":"PubMed","id":"8175689","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)","evidences":[{"source":"PubMed","id":"28770820","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.tetani tetanus toxin (tetX)","evidences":[{"source":"PubMed","id":"1331807","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type G (BoNT/G, botG)","evidences":[{"source":"PubMed","id":"7910017","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 124 |
| Details | Domain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)","evidences":[{"source":"PubMed","id":"7737992","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q16623","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 124 |
| Details | Domain: {"description":"t-SNARE coiled-coil homology 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
