6WU8
Structure of human SHP2 in complex with inhibitor IACS-13909
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 536 | 61491.4 | 2 | UniProt (Q06124) Pfam (PF00017) Pfam (PF00102) In PDB | Homo sapiens (Human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3 |
| 2 | A, B | 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine | non-polymer | 377.3 | 2 | Chemie (U9Y) | |||
| 3 | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 530 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Ala -4 | - | expression tag |
| Met -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Ile 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 122982.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 754.5 | |
| All* | Total formula weight | 123737.3 |
