6WPH
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)-FTC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H | polymer | 560 | 64521.9 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) | |
| 2 | B (B) | p51 RT | polymer | 452 | 52748.4 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) | |
| 3 | C (P) | DNA Primer 21-mer | polymer | 21 | 6476.2 | 1 | synthetic construct | ||
| 4 | D (T) | DNA template 27-mer | polymer | 27 | 8408.4 | 1 | synthetic construct | ||
| 5 | E, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | G (P) | [(2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl]methyl dihydrogen phosphate | non-polymer | 327.2 | 1 | Chemie (43X) PubChem (503018) PubChem (19962064) PubChem (22862720) | |||
| 7 | H, J (T) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | I (T) | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (DGP) PubChem (135398597) PubChem (135402021) PubChem (135596592) PubChem (135699677) PubChem (135794130) PubChem (135873587) PubChem (135873588) PubChem (135925427) PubChem (135933899) PubChem (136093899) PubChem (136269908) PubChem (136847913) PubChem (137226753) PubChem (137257916) | |||
| 9 | K, L, M, N (A, B, P, T) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P04585)
B: 1 - 440 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Cys 258 | Gln 845 | engineered mutation |
| Ser 280 | Cys 867 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ser -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ser 280 | Cys 867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 132155.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 915.2 | |
| All* | Total formula weight | 133070.1 |
