6WPH

Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and (-)-FTC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 601

Chain	Residue
A	ASP443
A	GLU478
A	ASP498
T	DC723

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG B 501

Chain	Residue
B	PRO272
B	PRO272
B	ILE274
B	ILE274

---

site_id	AC3
Number of Residues	5
Details	binding site for residue 43X P 901

Chain	Residue
A	GLN151
A	ASP185
P	DG822
T	DG705
A	ARG72

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 T 901

Chain	Residue
P	G47817
P	HOH1001
T	DG710
T	DC711

---

site_id	AC5
Number of Residues	3
Details	binding site for residue DGP T 902

Chain	Residue
B	VAL314
B	VAL317
T	DT724

---

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 T 903

Chain	Residue
T	DG707
T	DG708

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"RT 'primer grip'","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Motif: {"description":"Tryptophan repeat motif","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12206668","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 175

Chain

Residue

Details

---