6WO2
Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Growth factor receptor-bound protein 2 | polymer | 117 | 13758.5 | 2 | UniProt (P62993) Pfam (PF00017) | Homo sapiens (Human) | Adapter protein GRB2,Protein Ash,SH2/SH3 adapter GRB2 |
| 2 | C, D (C, D) | ACE-PTR-02K-ASN-U67 | polymer | 5 | 609.7 | 2 | synthetic construct | ||
| 3 | E (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 4 | F, H (A, B) | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 2 | Chemie (IPA) | |||
| 5 | G (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A, B: 53 - 163 (UniProt: P62993)
| PDB | External Database | Details |
|---|---|---|
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
| His 168 | - | expression tag |
| His 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 28736.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 183.3 | |
| All* | Total formula weight | 28919.6 |
