6WO2

Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Growth factor receptor-bound protein 2	polymer	117	13758.5	2	UniProt (P62993) Pfam (PF00017) In PDB	Homo sapiens (Human)	Adapter protein GRB2,Protein Ash,SH2/SH3 adapter GRB2
2	C, D	ACE-PTR-02K-ASN-U67	polymer	5	609.7	2		synthetic construct
3	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
4	A, B	ISOPROPYL ALCOHOL	non-polymer		60.1	2	Chemie (IPA)
5	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6		water	water		18.0	74	Chemie (HOH)

Sequence modifications

A, B: 53 - 163 (UniProt: P62993)

PDB	External Database	Details
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag
His 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	28736.4
Non-Polymers*	Number of molecules	4
	Total formula weight	183.3
All*	Total formula weight	28919.6

*Water molecules are not included.