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6WO2

Crystal Structure of the Grb2 SH2 Domain in Complex with a Tripeptide: Ac-pY-Ac6c-N-isohexyl

Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue CA A 201
ChainResidue
AHIS79
AGLU152
BHIS79
BARG149
BGLU152

site_idAC2
Number of Residues5
Detailsbinding site for residue IPA A 202
ChainResidue
CHOH101
AVAL105
AGLN106
AVAL122
C02K3

site_idAC3
Number of Residues6
Detailsbinding site for residue NA B 201
ChainResidue
BGLU54
BMET55
BHIS58
BHOH301
BHOH305
BHOH330

site_idAC4
Number of Residues3
Detailsbinding site for residue IPA B 202
ChainResidue
BGLU54
BHIS58
BASP150

site_idAC5
Number of Residues6
Detailsbinding site for Ligand U67 E 5 bound to ASN E 4
ChainResidue
AGLU89
ALYS109
ATHR138
CPTR2
C02K3
CASN4

site_idAC6
Number of Residues6
Detailsbinding site for Ligand U67 F 5 bound to ASN F 4
ChainResidue
AGLU72
ASER75
ALYS76
DPTR2
D02K3
DASN4

site_idAC7
Number of Residues13
Detailsbinding site for residues ACE E 1 and PTR E 2
ChainResidue
AARG67
AARG86
ASER88
ASER90
ASER96
AHIS107
ALYS109
ATRP121
AARG142
C02K3
CASN4
CU675
CHOH101

site_idAC8
Number of Residues16
Detailsbinding site for residues PTR E 2 and 02K E 3
ChainResidue
AARG67
AARG86
ASER88
ASER90
ASER90
ASER96
AGLN106
AHIS107
APHE108
ALYS109
ATRP121
AARG142
AIPA202
CACE1
CASN4
CU675

site_idAC9
Number of Residues10
Detailsbinding site for Di-peptide 02K E 3 and ASN E 4
ChainResidue
ASER90
AGLN106
AHIS107
APHE108
ALYS109
ALEU120
ATRP121
AIPA202
CPTR2
CU675

site_idAD1
Number of Residues14
Detailsbinding site for residues ACE F 1 and PTR F 2
ChainResidue
ASER75
BARG67
BARG86
BSER88
BGLU89
BSER90
BSER96
BHIS107
BLYS109
BHOH317
D02K3
DASN4
DU675
DHOH102

site_idAD2
Number of Residues18
Detailsbinding site for residues PTR F 2 and 02K F 3
ChainResidue
DU675
DHOH101
DHOH102
ASER75
AASN103
AASP104
BARG67
BARG86
BSER88
BGLU89
BSER90
BSER96
BGLN106
BHIS107
BPHE108
BLYS109
DACE1
DASN4

site_idAD3
Number of Residues14
Detailsbinding site for Di-peptide 02K F 3 and ASN F 4
ChainResidue
ASER75
AARG78
AASN103
AASP104
BGLN106
BHIS107
BPHE108
BLYS109
BLEU111
BLEU120
BTRP121
DPTR2
DU675
DHOH101

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS109
BLYS109

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34348893
ChainResidueDetails
ALYS109
BLYS109

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PDB entries from 2024-11-13

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