6WKR
PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, Q (T, F) | Ubiquitin | polymer | 76 | 8622.9 | 2 | UniProt (P0CG48) Pfam (PF00240) | Homo sapiens (Human) | |
| 2 | B (A) | Polycomb protein SUZ12 | polymer | 739 | 83181.9 | 1 | UniProt (Q15022) Pfam (PF09733) | Homo sapiens (Human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 3 | C (L) | Polycomb protein EED | polymer | 441 | 50267.7 | 1 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (Human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 4 | D (N) | Histone-binding protein RBBP4 | polymer | 425 | 47709.5 | 1 | UniProt (Q09028) Pfam (PF12265) Pfam (PF00400) | Homo sapiens (Human) | Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48 |
| 5 | E (C) | Histone-lysine N-methyltransferase EZH2 | polymer | 746 | 85492.3 | 1 | UniProt (Q15910) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Homo sapiens (Human) | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
| 6 | F, R (B, E) | Protein Jumonji | polymer | 450 | 49306.1 | 2 | UniProt (Q92833) | Homo sapiens (Human) | Jumonji/ARID domain-containing protein 2 |
| 7 | G (P) | Zinc finger protein AEBP2 | polymer | 295 | 33012.7 | 1 | UniProt (Q6ZN18) | Homo sapiens (Human) | Adipocyte enhancer-binding protein 2,AE-binding protein 2 |
| 8 | H (H) | DNA (314-MER) | polymer | 320 | 98186.1 | 1 | Homo sapiens | ||
| 9 | I, M (I, O) | Histone H3.2 | polymer | 136 | 15421.1 | 2 | UniProt (P84233) Pfam (PF00125) | Xenopus laevis (African clawed frog) | Histone H3 |
| 10 | J, N (J, Q) | Histone H4 | polymer | 103 | 11394.4 | 2 | UniProt (P62799) Pfam (PF15511) | Xenopus laevis (African clawed frog) | |
| 11 | K, O (K, R) | Histone H2A type 1 | polymer | 130 | 14067.4 | 2 | UniProt (P06897) Pfam (PF00125) Pfam (PF16211) | Xenopus laevis (African clawed frog) | |
| 12 | L, P (M, S) | Histone H2B 1.1 | polymer | 126 | 13979.3 | 2 | UniProt (P02281) Pfam (PF00125) | Xenopus laevis (African clawed frog) | H2B1.1 |
| 13 | S (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 14 | T (C) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 15 | U (P) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
T, F: 1 - 76 (UniProt: P0CG48)
K, R: 0 - 129 (UniProt: P06897)
M, S: -3 - 122 (UniProt: P02281)
| PDB | External Database | Details |
|---|---|---|
| Cys 76 | Gly 76 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Arg 99 | Gly 100 | conflict |
| Cys 119 | Lys 120 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Thr 29 | Ser 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 623432.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 474.1 | |
| All* | Total formula weight | 623906.7 |
