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6WKR

PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0001222molecular_functiontranscription corepressor binding
A0001739cellular_componentsex chromatin
A0003682molecular_functionchromatin binding
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005677cellular_componentchromatin silencing complex
A0005730cellular_componentnucleolus
A0006325biological_processchromatin organization
A0008047molecular_functionenzyme activator activity
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0016586cellular_componentRSC-type complex
A0016604cellular_componentnuclear body
A0031490molecular_functionchromatin DNA binding
A0032993cellular_componentprotein-DNA complex
A0035064molecular_functionmethylated histone binding
A0035098cellular_componentESC/E(Z) complex
A0043565molecular_functionsequence-specific DNA binding
A0045596biological_processnegative regulation of cell differentiation
A0046872molecular_functionmetal ion binding
A0048709biological_processoligodendrocyte differentiation
A0060816biological_processrandom inactivation of X chromosome
A0106222molecular_functionlncRNA binding
A0140718biological_processfacultative heterochromatin formation
A1990841molecular_functionpromoter-specific chromatin binding
A1990904cellular_componentribonucleoprotein complex
C0000082biological_processG1/S transition of mitotic cell cycle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0000976molecular_functiontranscription cis-regulatory region binding
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
C0001222molecular_functiontranscription corepressor binding
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003714molecular_functiontranscription corepressor activity
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005677cellular_componentchromatin silencing complex
C0005694cellular_componentchromosome
C0005721cellular_componentpericentric heterochromatin
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006346biological_processDNA methylation-dependent heterochromatin formation
C0006355biological_processregulation of DNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0008168molecular_functionmethyltransferase activity
C0008284biological_processpositive regulation of cell population proliferation
C0009913biological_processepidermal cell differentiation
C0010468biological_processregulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0014013biological_processregulation of gliogenesis
C0014834biological_processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
C0014898biological_processcardiac muscle hypertrophy in response to stress
C0016279molecular_functionprotein-lysine N-methyltransferase activity
C0021695biological_processcerebellar cortex development
C0021766biological_processhippocampus development
C0030097biological_processhemopoiesis
C0030183biological_processB cell differentiation
C0030216biological_processkeratinocyte differentiation
C0030335biological_processpositive regulation of cell migration
C0031048biological_processregulatory ncRNA-mediated heterochromatin formation
C0031490molecular_functionchromatin DNA binding
C0031491molecular_functionnucleosome binding
C0031507biological_processheterochromatin formation
C0031509biological_processsubtelomeric heterochromatin formation
C0032259biological_processmethylation
C0032355biological_processresponse to estradiol
C0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
C0035098cellular_componentESC/E(Z) complex
C0035984biological_processcellular response to trichostatin A
C0036211biological_processprotein modification process
C0036333biological_processhepatocyte homeostasis
C0042054molecular_functionhistone methyltransferase activity
C0042127biological_processregulation of cell population proliferation
C0042393molecular_functionhistone binding
C0042752biological_processregulation of circadian rhythm
C0043021molecular_functionribonucleoprotein complex binding
C0043406biological_processpositive regulation of MAP kinase activity
C0043547biological_processpositive regulation of GTPase activity
C0043565molecular_functionsequence-specific DNA binding
C0045120cellular_componentpronucleus
C0045202cellular_componentsynapse
C0045605biological_processnegative regulation of epidermal cell differentiation
C0045617biological_processnegative regulation of keratinocyte differentiation
C0045814biological_processnegative regulation of gene expression, epigenetic
C0045892biological_processnegative regulation of DNA-templated transcription
C0046976molecular_functionhistone H3K27 methyltransferase activity
C0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
C0048511biological_processrhythmic process
C0048863biological_processstem cell differentiation
C0050767biological_processregulation of neurogenesis
C0051154biological_processnegative regulation of striated muscle cell differentiation
C0051932biological_processsynaptic transmission, GABAergic
C0070301biological_processcellular response to hydrogen peroxide
C0070314biological_processG1 to G0 transition
C0070878molecular_functionprimary miRNA binding
C0071168biological_processprotein localization to chromatin
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0090183biological_processregulation of kidney development
C0097421biological_processliver regeneration
C0106222molecular_functionlncRNA binding
C0140718biological_processfacultative heterochromatin formation
C0140938molecular_functionhistone H3 methyltransferase activity
C0140951molecular_functionhistone H3K27 trimethyltransferase activity
C1900006biological_processpositive regulation of dendrite development
C1900016biological_processnegative regulation of cytokine production involved in inflammatory response
C1902808biological_processpositive regulation of cell cycle G1/S phase transition
C1904772biological_processresponse to tetrachloromethane
C1990841molecular_functionpromoter-specific chromatin binding
C2000134biological_processnegative regulation of G1/S transition of mitotic cell cycle
C2000737biological_processnegative regulation of stem cell differentiation
I0000786cellular_componentnucleosome
I0003677molecular_functionDNA binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005694cellular_componentchromosome
I0030527molecular_functionstructural constituent of chromatin
I0046982molecular_functionprotein heterodimerization activity
J0000786cellular_componentnucleosome
J0003677molecular_functionDNA binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005694cellular_componentchromosome
J0006334biological_processnucleosome assembly
J0030527molecular_functionstructural constituent of chromatin
J0046982molecular_functionprotein heterodimerization activity
K0000786cellular_componentnucleosome
K0003677molecular_functionDNA binding
K0005634cellular_componentnucleus
K0005694cellular_componentchromosome
K0030527molecular_functionstructural constituent of chromatin
K0046982molecular_functionprotein heterodimerization activity
L0000122biological_processnegative regulation of transcription by RNA polymerase II
L0001222molecular_functiontranscription corepressor binding
L0003682molecular_functionchromatin binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005694cellular_componentchromosome
L0005829cellular_componentcytosol
L0006325biological_processchromatin organization
L0008047molecular_functionenzyme activator activity
L0021510biological_processspinal cord development
L0031491molecular_functionnucleosome binding
L0031507biological_processheterochromatin formation
L0035098cellular_componentESC/E(Z) complex
L0042802molecular_functionidentical protein binding
L0045892biological_processnegative regulation of DNA-templated transcription
M0000786cellular_componentnucleosome
M0003677molecular_functionDNA binding
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005694cellular_componentchromosome
M0030527molecular_functionstructural constituent of chromatin
M0046982molecular_functionprotein heterodimerization activity
N0000118cellular_componenthistone deacetylase complex
N0000122biological_processnegative regulation of transcription by RNA polymerase II
N0000781cellular_componentchromosome, telomeric region
N0000785cellular_componentchromatin
N0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005694cellular_componentchromosome
N0005829cellular_componentcytosol
N0006260biological_processDNA replication
N0006325biological_processchromatin organization
N0006334biological_processnucleosome assembly
N0006335biological_processDNA replication-dependent chromatin assembly
N0006338biological_processchromatin remodeling
N0006355biological_processregulation of DNA-templated transcription
N0007420biological_processbrain development
N0008094molecular_functionATP-dependent activity, acting on DNA
N0008285biological_processnegative regulation of cell population proliferation
N0016581cellular_componentNuRD complex
N0016589cellular_componentNURF complex
N0030336biological_processnegative regulation of cell migration
N0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
N0031492molecular_functionnucleosomal DNA binding
N0032991cellular_componentprotein-containing complex
N0033186cellular_componentCAF-1 complex
N0035098cellular_componentESC/E(Z) complex
N0042393molecular_functionhistone binding
N0042659biological_processregulation of cell fate specification
N0042826molecular_functionhistone deacetylase binding
N0045892biological_processnegative regulation of DNA-templated transcription
N0045893biological_processpositive regulation of DNA-templated transcription
N0070822cellular_componentSin3-type complex
N1902455biological_processnegative regulation of stem cell population maintenance
N1902459biological_processpositive regulation of stem cell population maintenance
N1904949cellular_componentATPase complex
N2000736biological_processregulation of stem cell differentiation
O0000786cellular_componentnucleosome
O0003677molecular_functionDNA binding
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005694cellular_componentchromosome
O0030527molecular_functionstructural constituent of chromatin
O0046982molecular_functionprotein heterodimerization activity
Q0000786cellular_componentnucleosome
Q0003677molecular_functionDNA binding
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005694cellular_componentchromosome
Q0006334biological_processnucleosome assembly
Q0030527molecular_functionstructural constituent of chromatin
Q0046982molecular_functionprotein heterodimerization activity
R0000786cellular_componentnucleosome
R0003677molecular_functionDNA binding
R0005634cellular_componentnucleus
R0005694cellular_componentchromosome
R0030527molecular_functionstructural constituent of chromatin
R0046982molecular_functionprotein heterodimerization activity
S0000786cellular_componentnucleosome
S0003677molecular_functionDNA binding
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005694cellular_componentchromosome
S0030527molecular_functionstructural constituent of chromatin
S0046982molecular_functionprotein heterodimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue MG A 801
ChainResidue
APRO510
AALA513

site_idAC2
Number of Residues13
Detailsbinding site for residue SAH C 801
ChainResidue
CPHE665
CASN688
CHIS689
CTYR736
CVAL737
CILE739
CVAL621
CALA622
CGLY623
CTRP624
CMET662
CCYS663
CSER664

site_idAC3
Number of Residues3
Detailsbinding site for residue ZN P 301
ChainResidue
PCYS94
PHIS110
PMET111

Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues24
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CcwdqCqacFnsspdladHirsi.H
ChainResidueDetails
PCYS55-HIS78
PCYS122-HIS144
ACYS450-HIS471

site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
KALA21-VAL27

site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
JGLY14-HIS18

site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD
ChainResidueDetails
TLYS27-ASP52

site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
ILYS14-LEU20

site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
MARG89-GLY111

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
LLEU206-ILE220
NLEU193-ILE207
NLEU289-LEU303
NLEU333-LEU347

site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
IPRO66-ILE74

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0C1H4
ChainResidueDetails
MLYS2
MLYS9
MLYS12
MLYS17
SLYS2
SLYS9
SLYS12
SLYS17

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12757711
ChainResidueDetails
MSER11
SSER11

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807
ChainResidueDetails
MSER109
SSER109
RLYS9
RLYS95

site_idSWS_FT_FI4
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0C1H4
ChainResidueDetails
MLYS117
RLYS36
SLYS117
LLYS284

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P0C0S8
ChainResidueDetails
KLYS74
KLYS75
RLYS74
RLYS75
QLYS8
QLYS16
QLYS44
QLYS79

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N5-methylglutamine => ECO:0000250
ChainResidueDetails
KGLN104
RGLN104
QLYS12
QLYS20

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P0C0S8
ChainResidueDetails
KLYS118
RLYS118
QLYS31
QLYS91

site_idSWS_FT_FI8
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250
ChainResidueDetails
KLYS13
QSER47
KLYS15
KCYS119
RLYS13
RLYS15
RCYS119

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62805
ChainResidueDetails
JTYR51
JTYR88
QTYR51
QTYR88

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P62805
ChainResidueDetails
JLYS59
OLYS64
QLYS59
ILYS27
ILYS36
ILYS64
OLYS18
OLYS23
OLYS27
OLYS36

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62805
ChainResidueDetails
JLYS77
QLYS77

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805
ChainResidueDetails
JLYS31
QLYS31

site_idSWS_FT_FI13
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805
ChainResidueDetails
ILYS37
JLYS91
QLYS91

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
ITYR41
OTYR41

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228
ChainResidueDetails
ILYS56
ILYS79
OLYS56
OLYS79

site_idSWS_FT_FI16
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
ISER57
OSER57

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
ITHR80
ITHR107
OTHR80
OTHR107

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243
ChainResidueDetails
ISER86
OSER86

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
ILYS115
OLYS115

site_idSWS_FT_FI20
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
ILYS122
OLYS122

site_idSWS_FT_FI21
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
ICYS110
OCYS110

224572

PDB entries from 2024-09-04

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