6WI3
Histone deacetylases complex with peptide macrocycles
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Histone deacetylase 2 | polymer | 385 | 43897.9 | 3 | UniProt (Q92769) Pfam (PF00850) | Homo sapiens (Human) | HD2 |
| 2 | D, E, F (F, G, H) | (SHA)W(DTH)DN(DSN)(DME)(DAS)K peptide macrocycle | polymer | 9 | 1156.3 | 3 | synthetic construct | ||
| 3 | G, N, T (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | H, I, O, P, U... (A, B, C) | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 5 | J (A) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 1 | Chemie (NHE) | |||
| 6 | K, R, W, X (A, B, C) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 7 | L, M, Q, S (A, B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 4 | Chemie (PG4) | |||
| 8 | AA, BA, CA, Y, Z (C, F, G, A, B) | water | water | 18.0 | 448 | Chemie (HOH) |
Sequence modifications
A, B, C: 6 - 389 (UniProt: Q92769)
| PDB | External Database | Details |
|---|---|---|
| Ala 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 135162.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1919.1 | |
| All* | Total formula weight | 137081.8 |
