Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004407 | molecular_function | histone deacetylase activity |
B | 0004407 | molecular_function | histone deacetylase activity |
C | 0004407 | molecular_function | histone deacetylase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 401 |
Chain | Residue |
A | ASP181 |
A | HIS183 |
A | ASP269 |
F | U2M500 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue NA A 402 |
Chain | Residue |
A | ASP179 |
A | ASP181 |
A | HIS183 |
A | SER202 |
A | PHE203 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue NA A 403 |
Chain | Residue |
A | PHE192 |
A | THR195 |
A | VAL198 |
A | TYR227 |
A | HOH530 |
A | HOH572 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue NHE A 404 |
Chain | Residue |
A | LYS128 |
A | HOH569 |
B | ASP21 |
B | GLY22 |
B | ASP23 |
B | ARG60 |
site_id | AC5 |
Number of Residues | 1 |
Details | binding site for residue PGE A 405 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue PG4 A 406 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue PG4 A 407 |
Chain | Residue |
A | ARG311 |
A | GLU340 |
A | TYR341 |
A | GLY343 |
A | HOH522 |
C | PHE346 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN B 401 |
Chain | Residue |
B | ASP181 |
B | HIS183 |
B | ASP269 |
G | U2M500 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue NA B 402 |
Chain | Residue |
B | ASP179 |
B | ASP181 |
B | HIS183 |
B | SER202 |
B | PHE203 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue NA B 403 |
Chain | Residue |
B | PHE192 |
B | THR195 |
B | VAL198 |
B | TYR227 |
B | HOH549 |
B | HOH559 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue PG4 B 404 |
Chain | Residue |
A | ARG131 |
B | TYR27 |
B | ASP109 |
B | HOH513 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue PGE B 405 |
Chain | Residue |
B | ARG311 |
B | GLU340 |
B | TYR341 |
B | GLY343 |
B | HOH602 |
site_id | AD4 |
Number of Residues | 8 |
Details | binding site for residue PG4 B 406 |
Chain | Residue |
B | LYS94 |
B | LYS284 |
B | GLU328 |
B | ASN331 |
B | HIS349 |
C | GLU67 |
C | THR70 |
C | LYS71 |
site_id | AD5 |
Number of Residues | 4 |
Details | binding site for residue ZN C 401 |
Chain | Residue |
C | ASP181 |
C | HIS183 |
C | ASP269 |
H | U2M500 |
site_id | AD6 |
Number of Residues | 6 |
Details | binding site for residue NA C 402 |
Chain | Residue |
C | ASP179 |
C | ASP181 |
C | HIS183 |
C | SER202 |
C | PHE203 |
C | HIS204 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue NA C 403 |
Chain | Residue |
C | PHE192 |
C | THR195 |
C | VAL198 |
C | TYR227 |
C | HOH509 |
C | HOH524 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue PGE C 404 |
Chain | Residue |
B | PRO344 |
C | LEU169 |
C | ALA191 |
C | HOH511 |
site_id | AD9 |
Number of Residues | 3 |
Details | binding site for residue PGE C 405 |
Chain | Residue |
B | LYS71 |
B | TYR72 |
C | GLU91 |
site_id | AE1 |
Number of Residues | 16 |
Details | binding site for Ligand residues DSN F 505 through ASP F 503 bound to ASN F 504 |
Chain | Residue |
A | ZN401 |
F | ASN504 |
A | LYS15 |
A | GLY32 |
A | PRO34 |
A | ASP104 |
A | GLN133 |
A | HIS145 |
A | HIS146 |
A | GLY154 |
A | PHE155 |
A | ASP181 |
A | HIS183 |
A | PHE210 |
A | LEU276 |
A | TYR308 |
site_id | AE2 |
Number of Residues | 15 |
Details | binding site for Ligand residues DSN G 505 through ASP G 503 bound to ASN G 504 |
Chain | Residue |
B | GLY32 |
B | PRO34 |
B | ARG54 |
B | ASP104 |
B | HIS146 |
B | GLY154 |
B | PHE155 |
B | HIS183 |
B | PHE210 |
B | PRO211 |
B | ASP269 |
B | TYR308 |
B | ZN401 |
G | ASN504 |
G | HOH701 |
site_id | AE3 |
Number of Residues | 12 |
Details | binding site for Di-peptide U2M H 500 and TRP H 501 |
Chain | Residue |
C | GLY32 |
C | PRO34 |
C | ASP104 |
C | HIS146 |
C | GLY154 |
C | PHE155 |
C | HIS183 |
C | PHE210 |
C | ARG275 |
C | TYR308 |
C | ZN401 |
H | LYS508 |
site_id | AE4 |
Number of Residues | 9 |
Details | binding site for Di-peptide U2M H 500 and LYS H 508 |
Chain | Residue |
C | ASP104 |
C | HIS146 |
C | GLY154 |
C | PHE155 |
C | HIS183 |
C | PHE210 |
C | TYR308 |
C | ZN401 |
H | TRP501 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | HIS146 | |
B | HIS146 | |
C | HIS146 | |
Chain | Residue | Details |
A | ASP179 | |
B | ASP179 | |
B | ASP181 | |
B | HIS183 | |
B | PHE192 | |
B | THR195 | |
B | VAL198 | |
B | SER202 | |
B | PHE203 | |
B | ASP269 | |
C | ASP179 | |
A | ASP181 | |
C | ASP181 | |
C | HIS183 | |
C | PHE192 | |
C | THR195 | |
C | VAL198 | |
C | SER202 | |
C | PHE203 | |
C | ASP269 | |
A | HIS183 | |
A | PHE192 | |
A | THR195 | |
A | VAL198 | |
A | SER202 | |
A | PHE203 | |
A | ASP269 | |
Chain | Residue | Details |
A | TYR227 | |
B | TYR227 | |
C | TYR227 | |
Chain | Residue | Details |
A | LYS79 | |
B | LYS79 | |
C | LYS79 | |
Chain | Residue | Details |
A | LYS225 | |
B | LYS225 | |
C | LYS225 | |
Chain | Residue | Details |
A | CYS266 | |
A | CYS278 | |
B | CYS266 | |
B | CYS278 | |
C | CYS266 | |
C | CYS278 | |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS79 | |
B | LYS79 | |
C | LYS79 | |