6WCQ
Structure of a substrate-bound DQC ubiquitin ligase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S-phase kinase-associated protein 1 | polymer | 163 | 18680.0 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) | Homo sapiens (Human) | SKP1,Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 2 | B (B) | F-box/LRR-repeat protein 17 | polymer | 396 | 44970.0 | 1 | UniProt (Q9UF56) Pfam (PF12937) Pfam (PF13516) | Homo sapiens (Human) | F-box and leucine-rich repeat protein 17,F-box only protein 13 |
| 3 | C (C) | Kelch-like ECH-associated protein 1 | polymer | 631 | 70173.5 | 1 | UniProt (Q14145) Pfam (PF01344) Pfam (PF00651) Pfam (PF07707) | Homo sapiens (Human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
| 4 | D (D) | Cullin-1 | polymer | 434 | 49926.5 | 1 | UniProt (Q13616) Pfam (PF00888) | Homo sapiens (Human) | CUL-1 |
Sequence modifications
B: 310 - 701 (UniProt: Q9UF56)
C: 1 - 624 (UniProt: Q14145)
| PDB | External Database | Details |
|---|---|---|
| Gly 306 | - | expression tag |
| Glu 307 | - | expression tag |
| Phe 308 | - | expression tag |
| Met 309 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Ala 99 | Val 99 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 183750.0 | |
| All* | Total formula weight | 183750.0 |
