6WCQ

Structure of a substrate-bound DQC ubiquitin ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006513	biological_process	protein monoubiquitination
A	0008013	molecular_function	beta-catenin binding
A	0016567	biological_process	protein ubiquitination
A	0019005	cellular_component	SCF ubiquitin ligase complex
A	0019904	molecular_function	protein domain specific binding
A	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
A	0031519	cellular_component	PcG protein complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051457	biological_process	maintenance of protein location in nucleus
A	0070936	biological_process	protein K48-linked ubiquitination
A	0097602	molecular_function	cullin family protein binding
A	0140677	molecular_function	molecular function activator activity
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1990444	molecular_function	F-box domain binding
A	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
A	1990757	molecular_function	ubiquitin ligase activator activity
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001701	biological_process	in utero embryonic development
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005884	cellular_component	actin filament
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010506	biological_process	regulation of autophagy
C	0016234	cellular_component	inclusion body
C	0016567	biological_process	protein ubiquitination
C	0030496	cellular_component	midbody
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0032991	cellular_component	protein-containing complex
C	0034451	cellular_component	centriolar satellite
C	0034599	biological_process	cellular response to oxidative stress
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045604	biological_process	regulation of epidermal cell differentiation
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0071353	biological_process	cellular response to interleukin-4
C	0097718	molecular_function	disordered domain specific binding
C	0140416	molecular_function	transcription regulator inhibitor activity
C	1902883	biological_process	negative regulation of response to oxidative stress
C	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0031625	molecular_function	ubiquitin protein ligase binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	72
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"18251510","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29590092","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Cross-link: {"description":"N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Arg-Cys) (interchain with C-151 in KEAP1)","evidences":[{"source":"PubMed","id":"30323285","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Cys-Arg) (interchain with R-135 in KEAP1)","evidences":[{"source":"PubMed","id":"30323285","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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