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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6W6L

Cryo-EM structure of the human ribosome-TMCO1 translocon

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A60S ribosomal protein L8polymer25728088.91UniProt (P62917)
Pfam (PF03947)
Pfam (PF00181)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein uL2
2B60S ribosomal protein L3polymer40346211.11UniProt (P39023)
Pfam (PF00297)
In PDB		Homo sapiens (Human)HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3
3C60S ribosomal protein L4polymer42747804.61UniProt (P36578)
Pfam (PF00573)
Pfam (PF14374)
In PDB		Homo sapiens (Human)60S ribosomal protein L1,Large ribosomal subunit protein uL4
4D5.8S ribosomal RNApolymer15750449.81GenBank (555853)Homo sapiens (Human)
5E5S ribosomal RNApolymer11938385.81Homo sapiens (Human)
6F60S ribosomal protein L5polymer29734426.81UniProt (P46777)
Pfam (PF17144)
Pfam (PF14204)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein uL18
7G60S ribosomal protein L6polymer28832810.21UniProt (Q02878)
Pfam (PF03868)
Pfam (PF01159)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107
8H60S ribosomal protein L7polymer24829291.01UniProt (P18124)
Pfam (PF08079)
Pfam (PF00327)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein uL30
9I60S ribosomal protein L7apolymer26630061.81UniProt (P62424)
Pfam (PF01248)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3
10J60S ribosomal protein L9polymer19221899.51UniProt (P32969)
Pfam (PF00347)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein uL6
11K60S ribosomal protein L10polymer21424657.11UniProt (P27635)
Pfam (PF00252)
In PDB		Homo sapiens (Human)Laminin receptor homolog,Large ribosomal subunit protein uL16,Protein QM,Ribosomal protein L10,Tumor suppressor QM
12L60S ribosomal protein L11polymer17820288.51UniProt (P62913)
Pfam (PF00281)
Pfam (PF00673)
In PDB		Homo sapiens (Human)CLL-associated antigen KW-12,Large ribosomal subunit protein uL5
13M60S ribosomal protein L13polymer21124321.71UniProt (P26373)
Pfam (PF01294)
In PDB		Homo sapiens (Human)Breast basic conserved protein 1,Large ribosomal subunit protein eL13
14N60S ribosomal protein L14polymer21523485.01UniProt (P50914)
Pfam (PF01929)
In PDB		Homo sapiens (Human)CAG-ISL 7,Large ribosomal subunit protein eL14
15O60S ribosomal protein L15polymer20424207.31UniProt (P61313)
Pfam (PF00827)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL15
16P60S ribosomal protein L13apolymer20323633.41UniProt (P40429)
Pfam (PF00572)
In PDB		Homo sapiens (Human)23 kDa highly basic protein,Large ribosomal subunit protein uL13
17Q60S ribosomal protein L17polymer18421443.21UniProt (P18621)
Pfam (PF00237)
In PDB		Homo sapiens (Human)60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1
18R60S ribosomal protein L18polymer18821687.71UniProt (Q07020)
Pfam (PF17135)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL18
19S60S ribosomal protein L19polymer19623535.31UniProt (P84098)
Pfam (PF01280)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL19
20T60S ribosomal protein L18apolymer17620808.51UniProt (Q02543)
Pfam (PF01775)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL20
21U60S ribosomal protein L21polymer16018610.01UniProt (P46778)
Pfam (PF01157)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL21
22V60S ribosomal protein L22polymer12814813.01UniProt (P35268)
Pfam (PF01776)
In PDB		Homo sapiens (Human)EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22
23W60S ribosomal protein L23polymer14014892.51Homo sapiens (Human)
24X60S ribosomal protein L24polymer15717825.11UniProt (P83731)
Pfam (PF01246)
In PDB		Homo sapiens (Human)60S ribosomal protein L30,Large ribosomal subunit protein eL24
25Y60S ribosomal protein L23apolymer15617740.21UniProt (P62750)
Pfam (PF03939)
Pfam (PF00276)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein uL23
26Z60S ribosomal protein L26polymer14517303.41UniProt (P61254)
Pfam (PF16906)
Pfam (PF00467)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein uL24
27a60S ribosomal protein L27polymer13615835.81UniProt (P61353)
Pfam (PF00467)
Pfam (PF01777)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL27
28b60S ribosomal protein L27apolymer14816604.51UniProt (P46776)
Pfam (PF00828)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein uL15
29c60S ribosomal protein L29polymer15917804.31UniProt (P47914)
Pfam (PF01779)
In PDB		Homo sapiens (Human)Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29
30d60S ribosomal protein L30polymer11512805.11UniProt (P62888)
Pfam (PF01248)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL30
31e60S ribosomal protein L31polymer12514494.91Homo sapiens (Human)
32f60S ribosomal protein L32polymer13515898.91UniProt (P62910)
Pfam (PF01655)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL32
33g60S ribosomal protein L35apolymer11012564.71UniProt (P18077)
Pfam (PF01247)
In PDB		Homo sapiens (Human)Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33
34h60S ribosomal protein L34polymer11713326.11UniProt (P49207)
Pfam (PF01199)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL34
35i60S ribosomal protein L35polymer12314593.61UniProt (P42766)
Pfam (PF00831)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein uL29
36j60S ribosomal protein L36polymer10512290.91UniProt (Q9Y3U8)
Pfam (PF01158)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL36
37k60S ribosomal protein L37polymer9711111.01UniProt (P61927)
Pfam (PF01907)
In PDB		Homo sapiens (Human)G1.16
38l60S ribosomal protein L38polymer708238.91UniProt (P63173)
Pfam (PF01781)
In PDB		Homo sapiens (Human)
39m60S ribosomal protein L39polymer516426.81UniProt (P62891)
Pfam (PF00832)
In PDB		Homo sapiens (Human)
40o60S ribosomal protein L41polymer253473.51UniProt (P62945)
Pfam (PF05162)
In PDB		Homo sapiens (Human)HG12,Large ribosomal subunit protein eL41
41p60S ribosomal protein L36apolymer10612477.01UniProt (J3KQN4)
Pfam (PF00935)
In PDB		Homo sapiens (Human)
42q60S ribosomal protein L37apolymer9210299.41UniProt (P61513)
Pfam (PF01780)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL43
43r60S ribosomal protein L28polymer13715784.61UniProt (P46779)
Pfam (PF01778)
In PDB		Homo sapiens (Human)Large ribosomal subunit protein eL28
44t28S ribosomal RNApolymer35791159525.81Homo sapiens (Human)
45utRNApolymer7624414.51Homo sapiens (Human)
46vtRNApolymer7624436.51Homo sapiens (Human)
47yNascent chain mixturepolymer272315.81Homo sapiens (Human)
481Protein transport protein Sec61 subunit alpha isoform 1polymer47652295.41UniProt (P61619)
Pfam (PF10559)
Pfam (PF00344)
In PDB		Homo sapiens (Human)Sec61 alpha-1
492Protein transport protein Sec61 subunit gammapolymer687752.31UniProt (P60059)
Pfam (PF00584)
In PDB		Homo sapiens (Human)
503Protein transport protein Sec61 subunit betapolymer969987.51UniProt (P60468)
Pfam (PF03911)
In PDB		Homo sapiens (Human)
514Transmembrane protein 147polymer22425279.81UniProt (Q9BVK8)
Pfam (PF09767)
In PDB		Homo sapiens (Human)Protein NIFIE 14
525Nicalinpolymer56363047.11UniProt (Q969V3)
Pfam (PF04389)
In PDB		Homo sapiens (Human)Nicastrin-like protein
537Coiled-coil domain-containing protein 47polymer48355946.81UniProt (Q96A33)
Pfam (PF07946)
In PDB		Homo sapiens (Human)Calumin
546Calcium load-activated calcium channelpolymer18821205.01UniProt (Q9UM00)
Pfam (PF01956)
In PDB		Homo sapiens (Human)CLAC channel,Transmembrane and coiled-coil domain-containing protein 1,Transmembrane and coiled-coil domains protein 4,Xenogeneic cross-immune protein PCIA3
55t, B, D, E, k...MAGNESIUM IONnon-polymer24.328Chemie (MG)
56k, p, qZINC IONnon-polymer65.43Chemie (ZN)
57waterwater18.01Chemie (HOH)
Sequence modifications
1: 1 - 476 (UniProt: P61619)
PDBExternal DatabaseDetails
Ser 145Ala 145conflict
His 343Tyr 343conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains54
Total formula weight2348917.6
Non-Polymers*Number of molecules31
Total formula weight876.8
All*Total formula weight2349794.4
*Water molecules are not included.

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PDB entries from 2024-07-17

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