6W6L
Cryo-EM structure of the human ribosome-TMCO1 translocon
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 60S ribosomal protein L8 | polymer | 257 | 28088.9 | 1 | UniProt (P62917) Pfam (PF03947) Pfam (PF00181) | Homo sapiens (Human) | Large ribosomal subunit protein uL2 |
| 2 | B (B) | 60S ribosomal protein L3 | polymer | 403 | 46211.1 | 1 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (Human) | HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3 |
| 3 | C (C) | 60S ribosomal protein L4 | polymer | 427 | 47804.6 | 1 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (Human) | 60S ribosomal protein L1,Large ribosomal subunit protein uL4 |
| 4 | D (D) | 5.8S ribosomal RNA | polymer | 157 | 50449.8 | 1 | GenBank (555853) | Homo sapiens (Human) | |
| 5 | E (E) | 5S ribosomal RNA | polymer | 119 | 38385.8 | 1 | Homo sapiens (Human) | ||
| 6 | F (F) | 60S ribosomal protein L5 | polymer | 297 | 34426.8 | 1 | UniProt (P46777) Pfam (PF17144) Pfam (PF14204) | Homo sapiens (Human) | Large ribosomal subunit protein uL18 |
| 7 | G (G) | 60S ribosomal protein L6 | polymer | 288 | 32810.2 | 1 | UniProt (Q02878) Pfam (PF03868) Pfam (PF01159) | Homo sapiens (Human) | Large ribosomal subunit protein eL6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107 |
| 8 | H (H) | 60S ribosomal protein L7 | polymer | 248 | 29291.0 | 1 | UniProt (P18124) Pfam (PF08079) Pfam (PF00327) | Homo sapiens (Human) | Large ribosomal subunit protein uL30 |
| 9 | I (I) | 60S ribosomal protein L7a | polymer | 266 | 30061.8 | 1 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (Human) | Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3 |
| 10 | J (J) | 60S ribosomal protein L9 | polymer | 192 | 21899.5 | 1 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (Human) | Large ribosomal subunit protein uL6 |
| 11 | K (K) | 60S ribosomal protein L10 | polymer | 214 | 24657.1 | 1 | UniProt (P27635) Pfam (PF00252) | Homo sapiens (Human) | Laminin receptor homolog,Large ribosomal subunit protein uL16,Protein QM,Ribosomal protein L10,Tumor suppressor QM |
| 12 | L (L) | 60S ribosomal protein L11 | polymer | 178 | 20288.5 | 1 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (Human) | CLL-associated antigen KW-12,Large ribosomal subunit protein uL5 |
| 13 | M (M) | 60S ribosomal protein L13 | polymer | 211 | 24321.7 | 1 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (Human) | Breast basic conserved protein 1,Large ribosomal subunit protein eL13 |
| 14 | N (N) | 60S ribosomal protein L14 | polymer | 215 | 23485.0 | 1 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (Human) | CAG-ISL 7,Large ribosomal subunit protein eL14 |
| 15 | O (O) | 60S ribosomal protein L15 | polymer | 204 | 24207.3 | 1 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (Human) | Large ribosomal subunit protein eL15 |
| 16 | P (P) | 60S ribosomal protein L13a | polymer | 203 | 23633.4 | 1 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (Human) | 23 kDa highly basic protein,Large ribosomal subunit protein uL13 |
| 17 | Q (Q) | 60S ribosomal protein L17 | polymer | 184 | 21443.2 | 1 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (Human) | 60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1 |
| 18 | R (R) | 60S ribosomal protein L18 | polymer | 188 | 21687.7 | 1 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (Human) | Large ribosomal subunit protein eL18 |
| 19 | S (S) | 60S ribosomal protein L19 | polymer | 196 | 23535.3 | 1 | UniProt (P84098) Pfam (PF01280) | Homo sapiens (Human) | Large ribosomal subunit protein eL19 |
| 20 | T (T) | 60S ribosomal protein L18a | polymer | 176 | 20808.5 | 1 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (Human) | Large ribosomal subunit protein eL20 |
| 21 | U (U) | 60S ribosomal protein L21 | polymer | 160 | 18610.0 | 1 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (Human) | Large ribosomal subunit protein eL21 |
| 22 | V (V) | 60S ribosomal protein L22 | polymer | 128 | 14813.0 | 1 | UniProt (P35268) Pfam (PF01776) | Homo sapiens (Human) | EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22 |
| 23 | W (W) | 60S ribosomal protein L23 | polymer | 140 | 14892.5 | 1 | Homo sapiens (Human) | ||
| 24 | X (X) | 60S ribosomal protein L24 | polymer | 157 | 17825.1 | 1 | UniProt (P83731) Pfam (PF01246) | Homo sapiens (Human) | 60S ribosomal protein L30,Large ribosomal subunit protein eL24 |
| 25 | Y (Y) | 60S ribosomal protein L23a | polymer | 156 | 17740.2 | 1 | UniProt (P62750) Pfam (PF03939) Pfam (PF00276) | Homo sapiens (Human) | Large ribosomal subunit protein uL23 |
| 26 | Z (Z) | 60S ribosomal protein L26 | polymer | 145 | 17303.4 | 1 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (Human) | Large ribosomal subunit protein uL24 |
| 27 | AA (a) | 60S ribosomal protein L27 | polymer | 136 | 15835.8 | 1 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (Human) | Large ribosomal subunit protein eL27 |
| 28 | BA (b) | 60S ribosomal protein L27a | polymer | 148 | 16604.5 | 1 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (Human) | Large ribosomal subunit protein uL15 |
| 29 | CA (c) | 60S ribosomal protein L29 | polymer | 159 | 17804.3 | 1 | UniProt (P47914) Pfam (PF01779) | Homo sapiens (Human) | Cell surface heparin-binding protein HIP,Large ribosomal subunit protein eL29 |
| 30 | DA (d) | 60S ribosomal protein L30 | polymer | 115 | 12805.1 | 1 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (Human) | Large ribosomal subunit protein eL30 |
| 31 | EA (e) | 60S ribosomal protein L31 | polymer | 125 | 14494.9 | 1 | Homo sapiens (Human) | ||
| 32 | FA (f) | 60S ribosomal protein L32 | polymer | 135 | 15898.9 | 1 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (Human) | Large ribosomal subunit protein eL32 |
| 33 | GA (g) | 60S ribosomal protein L35a | polymer | 110 | 12564.7 | 1 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (Human) | Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33 |
| 34 | HA (h) | 60S ribosomal protein L34 | polymer | 117 | 13326.1 | 1 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (Human) | Large ribosomal subunit protein eL34 |
| 35 | IA (i) | 60S ribosomal protein L35 | polymer | 123 | 14593.6 | 1 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (Human) | Large ribosomal subunit protein uL29 |
| 36 | JA (j) | 60S ribosomal protein L36 | polymer | 105 | 12290.9 | 1 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (Human) | Large ribosomal subunit protein eL36 |
| 37 | KA (k) | 60S ribosomal protein L37 | polymer | 97 | 11111.0 | 1 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (Human) | G1.16 |
| 38 | LA (l) | 60S ribosomal protein L38 | polymer | 70 | 8238.9 | 1 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (Human) | |
| 39 | MA (m) | 60S ribosomal protein L39 | polymer | 51 | 6426.8 | 1 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (Human) | |
| 40 | NA (o) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (Human) | HG12,Large ribosomal subunit protein eL41 |
| 41 | OA (p) | 60S ribosomal protein L36a | polymer | 106 | 12477.0 | 1 | UniProt (J3KQN4) Pfam (PF00935) | Homo sapiens (Human) | |
| 42 | PA (q) | 60S ribosomal protein L37a | polymer | 92 | 10299.4 | 1 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (Human) | Large ribosomal subunit protein eL43 |
| 43 | QA (r) | 60S ribosomal protein L28 | polymer | 137 | 15784.6 | 1 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (Human) | Large ribosomal subunit protein eL28 |
| 44 | RA (t) | 28S ribosomal RNA | polymer | 3579 | 1159525.8 | 1 | Homo sapiens (Human) | ||
| 45 | SA (u) | tRNA | polymer | 76 | 24414.5 | 1 | Homo sapiens (Human) | ||
| 46 | TA (v) | tRNA | polymer | 76 | 24436.5 | 1 | Homo sapiens (Human) | ||
| 47 | UA (y) | Nascent chain mixture | polymer | 27 | 2315.8 | 1 | Homo sapiens (Human) | ||
| 48 | VA (1) | Protein transport protein Sec61 subunit alpha isoform 1 | polymer | 476 | 52295.4 | 1 | UniProt (P61619) Pfam (PF10559) Pfam (PF00344) | Homo sapiens (Human) | Sec61 alpha-1 |
| 49 | WA (2) | Protein transport protein Sec61 subunit gamma | polymer | 68 | 7752.3 | 1 | UniProt (P60059) Pfam (PF00584) | Homo sapiens (Human) | |
| 50 | XA (3) | Protein transport protein Sec61 subunit beta | polymer | 96 | 9987.5 | 1 | UniProt (P60468) Pfam (PF03911) | Homo sapiens (Human) | |
| 51 | YA (4) | Transmembrane protein 147 | polymer | 224 | 25279.8 | 1 | UniProt (Q9BVK8) Pfam (PF09767) | Homo sapiens (Human) | Protein NIFIE 14 |
| 52 | ZA (5) | Nicalin | polymer | 563 | 63047.1 | 1 | UniProt (Q969V3) Pfam (PF04389) | Homo sapiens (Human) | Nicastrin-like protein |
| 53 | AB (7) | Coiled-coil domain-containing protein 47 | polymer | 483 | 55946.8 | 1 | UniProt (Q96A33) Pfam (PF07946) | Homo sapiens (Human) | Calumin |
| 54 | BB (6) | Calcium load-activated calcium channel | polymer | 188 | 21205.0 | 1 | UniProt (Q9UM00) Pfam (PF01956) | Homo sapiens (Human) | CLAC channel,Transmembrane and coiled-coil domain-containing protein 1,Transmembrane and coiled-coil domains protein 4,Xenogeneic cross-immune protein PCIA3 |
| 55 | AC, BC, CB, CC, DB... (t, B, D, E, k...) | MAGNESIUM ION | non-polymer | 24.3 | 28 | Chemie (MG) | |||
| 56 | TB, VB, WB (k, p, q) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 57 | HC (u) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
1: 1 - 476 (UniProt: P61619)
| PDB | External Database | Details |
|---|---|---|
| Ser 145 | Ala 145 | conflict |
| His 343 | Tyr 343 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 54 |
| Total formula weight | 2348917.6 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 876.8 | |
| All* | Total formula weight | 2349794.4 |
