6W4M
CRYSTAL STRUCTURE OF THE ADCC-POTENT, WEAKLY NEUTRALIZING HIV ENV CO-RECEPTOR BINDING SITE ANTIBODY N12-I2 FAB IN COMPLEX WITH HIV-1 CLADE A/E GP120 AND M48U1
Replaces: 5UWEEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (G) | clade A/E 93TH057 HIV-1 gp120 core | polymer | 353 | 39160.4 | 1 | UniProt (A0A0M3KKW9) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 2 | B (L) | ANTI-HIV ANTIBODY N12-I2 FAB LIGHT CHAIN | polymer | 215 | 23438.0 | 1 | Homo sapiens (Human) | ||
| 3 | C (H) | ANTI-HIV ANTIBODY N12-I2 FAB HEAVY CHAIN | polymer | 239 | 25810.7 | 1 | Homo sapiens (Human) | ||
| 4 | D (N) | M48U1 CD4 MIMETIC PEPTIDE | polymer | 28 | 3056.8 | 1 | synthetic construct | ||
| 5 | E, F, G, H, I... (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) |
Sequence modifications
G: 44 - 492 (UniProt: A0A0M3KKW9)
| PDB | External Database | Details |
|---|---|---|
| Ser 375 | His 242 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 91465.9 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1990.9 | |
| All* | Total formula weight | 93456.7 |
