6W3H

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	ATV Fc	polymer	227	25578.8	2		Homo sapiens
2	B, C (C, D)	Transferrin receptor protein 1,Transferrin receptor protein 1	polymer	166	17953.3	2	UniProt (P02786) Pfam (PF02225)	Homo sapiens (Human)	Trfr,T9,p90,Trfr,T9,p90
3	E (E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1317.2	1	In PDB GlyTouCan (G39213VZ)

Sequence modifications

C, D: 22 - 75 (UniProt: P02786)

PDB	External Database	Details
Thr 21	-	expression tag

C, D: 76 - 178 (UniProt: P02786)

PDB	External Database	Details
Ala 179	-	linker
Ser 180	-	linker
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	87064.2
Branched	Number of molecules	1
	Total formula weight	1317.2
All*	Total formula weight	88381.4

*Water molecules are not included.