6W3H

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004998	molecular_function	transferrin receptor activity
C	0005886	cellular_component	plasma membrane
C	0006879	biological_process	cellular iron ion homeostasis
C	0006898	biological_process	receptor-mediated endocytosis
C	0033572	biological_process	transferrin transport
D	0004998	molecular_function	transferrin receptor activity
D	0005886	cellular_component	plasma membrane
D	0006879	biological_process	cellular iron ion homeostasis
D	0006898	biological_process	receptor-mediated endocytosis
D	0033572	biological_process	transferrin transport

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FSCSVMH

Chain	Residue	Details
A	PHE423-HIS429

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10531064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CX8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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