6W1S
Atomic model of the mammalian Mediator complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mediator of RNA polymerase II transcription subunit 1 | polymer | 382 | 32528.0 | 1 | Mus musculus (Mouse) | ||
| 2 | B (B) | Mediator of RNA polymerase II transcription subunit 4 | polymer | 100 | 11647.3 | 1 | UniProt (Q9CQA5) Pfam (PF10018) | Mus musculus (Mouse) | Mediator complex subunit 4 |
| 3 | C (C) | Mediator of RNA polymerase II transcription subunit 6 | polymer | 246 | 28473.6 | 1 | UniProt (Q921D4) Pfam (PF04934) | Mus musculus (Mouse) | Mediator complex subunit 6 |
| 4 | D (D) | Mediator of RNA polymerase II transcription subunit 7 | polymer | 157 | 18837.0 | 1 | UniProt (Q9CZB6) Pfam (PF05983) | Mus musculus (Mouse) | Cofactor required for Sp1 transcriptional activation subunit 9,CRSP complex subunit 9,Mediator complex subunit 7 |
| 5 | E (E) | Mediator of RNA polymerase II transcription subunit 8 | polymer | 180 | 20156.7 | 1 | UniProt (Q9D7W5) Pfam (PF10232) | Mus musculus (Mouse) | Activator-recruited cofactor 32 kDa component,ARC32,Mediator complex subunit 8 |
| 6 | F (F) | Mediator of RNA polymerase II transcription subunit 9 | polymer | 76 | 8924.4 | 1 | UniProt (Q8VCS6) Pfam (PF07544) | Mus musculus (Mouse) | Mediator complex subunit 9 |
| 7 | G (G) | Mediator of RNA polymerase II transcription subunit 10 | polymer | 155 | 15951.9 | 1 | UniProt (Q9CXU0) Pfam (PF09748) | Mus musculus (Mouse) | Mediator complex subunit 10 |
| 8 | H (H) | Mediator of RNA polymerase II transcription subunit 11 | polymer | 108 | 12166.7 | 1 | UniProt (Q9D8C6) Pfam (PF10280) | Mus musculus (Mouse) | Mediator complex subunit 11 |
| 9 | I (I) | Mediator of RNA polymerase II transcription subunit 14 | polymer | 1548 | 168719.5 | 1 | UniProt (A2ABV5) Pfam (PF22984) Pfam (PF22983) Pfam (PF08638) Pfam (PF22981) | Mus musculus (Mouse) | Cofactor required for Sp1 transcriptional activation subunit 2,CRSP complex subunit 2,Mediator complex subunit 14,Thyroid hormone receptor-associated protein complex 170 kDa component,Trap170 |
| 10 | J (J) | Mediator of RNA polymerase II transcription subunit 15 | polymer | 167 | 18904.7 | 1 | UniProt (Q924H2) Pfam (PF21539) | Mus musculus (Mouse) | Mediator complex subunit 15,Positive cofactor 2 glutamine/Q-rich-associated protein,mPcqap |
| 11 | K (K) | Mediator of RNA polymerase II transcription subunit 16 | polymer | 828 | 91890.5 | 1 | UniProt (Q6PGF3) Pfam (PF00400) Pfam (PF11635) Pfam (PF20718) Pfam (PF20719) | Mus musculus (Mouse) | Mediator complex subunit 16,Thyroid hormone receptor-associated protein 5,Thyroid hormone receptor-associated protein complex 95 kDa component,Trap95,Vitamin D3 receptor-interacting protein complex 92 kDa component,DRIP92 |
| 12 | L (L) | Mediator of RNA polymerase II transcription subunit 17 | polymer | 631 | 70669.3 | 1 | UniProt (Q8VCD5) Pfam (PF10156) | Mus musculus (Mouse) | Cofactor required for Sp1 transcriptional activation subunit 6,CRSP complex subunit 6,Mediator complex subunit 17,Thyroid hormone receptor-associated protein complex 80 kDa component |
| 13 | M (M) | Mediator of RNA polymerase II transcription subunit 18 | polymer | 187 | 21433.8 | 1 | UniProt (Q9CZ82) Pfam (PF09637) | Mus musculus (Mouse) | Mediator complex subunit 18 |
| 14 | N (N) | Mediator of RNA polymerase II transcription subunit 19 | polymer | 243 | 24684.6 | 1 | UniProt (Q8C1S0) Pfam (PF10278) | Mus musculus (Mouse) | Mediator complex subunit 19 |
| 15 | O (O) | Mediator of RNA polymerase II transcription subunit 20 | polymer | 198 | 21660.9 | 1 | UniProt (Q9R0X0) Pfam (PF08612) | Mus musculus (Mouse) | Mediator complex subunit 20,TRF-proximal protein homolog |
| 16 | P (P) | Mediator of RNA polymerase II transcription subunit 21 | polymer | 126 | 13619.1 | 1 | UniProt (Q9CQ39) Pfam (PF11221) | Mus musculus (Mouse) | Mediator complex subunit 21,RNA polymerase II holoenzyme component SRB7,RNAPII complex component SRB7 |
| 17 | Q (Q) | Mediator of RNA polymerase II transcription subunit 22 | polymer | 131 | 15284.0 | 1 | UniProt (Q62276) Pfam (PF06179) | Mus musculus (Mouse) | Mediator complex subunit 22,Surfeit locus protein 5,Surf-5 |
| 18 | R (R) | Mediator of RNA polymerase II transcription subunit 23 | polymer | 1367 | 156265.7 | 1 | UniProt (Q80YQ2) Pfam (PF11573) | Mus musculus (Mouse) | Cofactor required for Sp1 transcriptional activation subunit 3,CRSP complex subunit 3,Mediator complex subunit 23,Protein sur-2 homolog,mSur-2 |
| 19 | S (S) | Mediator of RNA polymerase II transcription subunit 24 | polymer | 982 | 109563.1 | 1 | UniProt (Q99K74) Pfam (PF11277) | Mus musculus (Mouse) | Mediator complex subunit 24,Thyroid hormone receptor-associated protein 4,Thyroid hormone receptor-associated protein complex 100 kDa component,mTRAP100 |
| 20 | T (T) | Mediator of RNA polymerase II transcription subunit 25 | polymer | 202 | 22032.9 | 1 | UniProt (Q8VCB2) Pfam (PF11265) | Mus musculus (Mouse) | Mediator complex subunit 25,mMED25 |
| 21 | U (V) | Mediator of RNA polymerase II transcription subunit 27 | polymer | 297 | 33737.8 | 1 | UniProt (Q9DB40) Pfam (PF11571) | Mus musculus (Mouse) | Cofactor required for Sp1 transcriptional activation subunit 8,CRSP complex subunit 8,Mediator complex subunit 27 |
| 22 | V (W) | Mediator of RNA polymerase II transcription subunit 28 | polymer | 118 | 13531.2 | 1 | UniProt (Q920D3) Pfam (PF11594) | Mus musculus (Mouse) | Mediator complex subunit 28 |
| 23 | W (X) | Mediator of RNA polymerase II transcription subunit 29 | polymer | 134 | 14965.2 | 1 | UniProt (Q9DB91) Pfam (PF11568) | Mus musculus (Mouse) | Intersex-like protein,Mediator complex subunit 29 |
| 24 | X (Y) | Mediator of RNA polymerase II transcription subunit 30 | polymer | 152 | 17873.5 | 1 | UniProt (Q9CQI9) Pfam (PF11315) | Mus musculus (Mouse) | Mediator complex subunit 30,Thyroid hormone receptor-associated protein 6,Thyroid hormone receptor-associated protein complex 25 kDa component,Trap25 |
| 25 | Y (Z) | Mediator of RNA polymerase II transcription subunit 31 | polymer | 93 | 11545.4 | 1 | UniProt (Q9CXU1) Pfam (PF05669) | Mus musculus (Mouse) | Mediator complex subunit 31,Mediator complex subunit SOH1 |
Sequence modifications
G: 200 - 269 (PDB: 6W1S)
G: 270 - 354 (UniProt: Q9CXU0)
I: 1 - 1999 (UniProt: A2ABV5)
I: 2000 - 2097 (PDB: 6W1S)
N: 423 - 499 (UniProt: Q8C1S0)
N: 500 - 589 (PDB: 6W1S)
N: 590 - 697 (UniProt: Q8C1S0)
G: 270 - 354 (UniProt: Q9CXU0)
I: 1 - 1999 (UniProt: A2ABV5)
I: 2000 - 2097 (PDB: 6W1S)
N: 423 - 499 (UniProt: Q8C1S0)
N: 500 - 589 (PDB: 6W1S)
N: 590 - 697 (UniProt: Q8C1S0)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 25 |
| Total formula weight | 975066.8 | |
| All* | Total formula weight | 975066.8 |
