Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6W1S

Atomic model of the mammalian Mediator complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003712	molecular_function	transcription coregulator activity
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016592	cellular_component	mediator complex
C	0000151	cellular_component	ubiquitin ligase complex
C	0001223	molecular_function	transcription coactivator binding
C	0003677	molecular_function	DNA binding
C	0003712	molecular_function	transcription coregulator activity
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016567	biological_process	protein ubiquitination
C	0016592	cellular_component	mediator complex
C	0019827	biological_process	stem cell population maintenance
C	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051123	biological_process	RNA polymerase II preinitiation complex assembly
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070847	cellular_component	core mediator complex
D	0003712	molecular_function	transcription coregulator activity
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016592	cellular_component	mediator complex
E	0003712	molecular_function	transcription coregulator activity
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0016592	cellular_component	mediator complex
F	0003712	molecular_function	transcription coregulator activity
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016592	cellular_component	mediator complex
G	0003712	molecular_function	transcription coregulator activity
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0016592	cellular_component	mediator complex
H	0000151	cellular_component	ubiquitin ligase complex
H	0003712	molecular_function	transcription coregulator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0006351	biological_process	DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0016567	biological_process	protein ubiquitination
H	0016592	cellular_component	mediator complex
H	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0070847	cellular_component	core mediator complex
I	0003712	molecular_function	transcription coregulator activity
I	0003713	molecular_function	transcription coactivator activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0006351	biological_process	DNA-templated transcription
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0016592	cellular_component	mediator complex
I	0016604	cellular_component	nuclear body
I	0019827	biological_process	stem cell population maintenance
I	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0070847	cellular_component	core mediator complex
K	0003713	molecular_function	transcription coactivator activity
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0016592	cellular_component	mediator complex
K	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0046966	molecular_function	nuclear thyroid hormone receptor binding
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
K	0070847	cellular_component	core mediator complex
L	0000151	cellular_component	ubiquitin ligase complex
L	0003712	molecular_function	transcription coregulator activity
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005667	cellular_component	transcription regulator complex
L	0006351	biological_process	DNA-templated transcription
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0016567	biological_process	protein ubiquitination
L	0016592	cellular_component	mediator complex
L	0019827	biological_process	stem cell population maintenance
L	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046966	molecular_function	nuclear thyroid hormone receptor binding
L	0051123	biological_process	RNA polymerase II preinitiation complex assembly
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0070847	cellular_component	core mediator complex
M	0000151	cellular_component	ubiquitin ligase complex
M	0003712	molecular_function	transcription coregulator activity
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0006351	biological_process	DNA-templated transcription
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0016567	biological_process	protein ubiquitination
M	0016592	cellular_component	mediator complex
M	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
M	0061630	molecular_function	ubiquitin protein ligase activity
M	0070847	cellular_component	core mediator complex
N	0003712	molecular_function	transcription coregulator activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0006351	biological_process	DNA-templated transcription
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0016592	cellular_component	mediator complex
N	0016604	cellular_component	nuclear body
N	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0051123	biological_process	RNA polymerase II preinitiation complex assembly
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0070847	cellular_component	core mediator complex
O	0000151	cellular_component	ubiquitin ligase complex
O	0003712	molecular_function	transcription coregulator activity
O	0003713	molecular_function	transcription coactivator activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0006351	biological_process	DNA-templated transcription
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0016567	biological_process	protein ubiquitination
O	0016592	cellular_component	mediator complex
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0032991	cellular_component	protein-containing complex
O	0035914	biological_process	skeletal muscle cell differentiation
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0061630	molecular_function	ubiquitin protein ligase activity
O	0070847	cellular_component	core mediator complex
P	0016592	cellular_component	mediator complex
Q	0003712	molecular_function	transcription coregulator activity
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0016592	cellular_component	mediator complex
R	0000151	cellular_component	ubiquitin ligase complex
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005667	cellular_component	transcription regulator complex
R	0006351	biological_process	DNA-templated transcription
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0010628	biological_process	positive regulation of gene expression
R	0016567	biological_process	protein ubiquitination
R	0016592	cellular_component	mediator complex
R	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0070847	cellular_component	core mediator complex
R	2000409	biological_process	positive regulation of T cell extravasation
S	0000151	cellular_component	ubiquitin ligase complex
S	0003712	molecular_function	transcription coregulator activity
S	0003713	molecular_function	transcription coactivator activity
S	0004402	molecular_function	histone acetyltransferase activity
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0006338	biological_process	chromatin remodeling
S	0006351	biological_process	DNA-templated transcription
S	0006366	biological_process	transcription by RNA polymerase II
S	0016567	biological_process	protein ubiquitination
S	0016592	cellular_component	mediator complex
S	0019827	biological_process	stem cell population maintenance
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0044877	molecular_function	protein-containing complex binding
S	0045893	biological_process	positive regulation of DNA-templated transcription
S	0046966	molecular_function	nuclear thyroid hormone receptor binding
S	0051123	biological_process	RNA polymerase II preinitiation complex assembly
S	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
S	0061630	molecular_function	ubiquitin protein ligase activity
S	0070847	cellular_component	core mediator complex
V	0000151	cellular_component	ubiquitin ligase complex
V	0003713	molecular_function	transcription coactivator activity
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005667	cellular_component	transcription regulator complex
V	0005730	cellular_component	nucleolus
V	0005829	cellular_component	cytosol
V	0006351	biological_process	DNA-templated transcription
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0016567	biological_process	protein ubiquitination
V	0016592	cellular_component	mediator complex
V	0019827	biological_process	stem cell population maintenance
V	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
V	0051123	biological_process	RNA polymerase II preinitiation complex assembly
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
V	0061630	molecular_function	ubiquitin protein ligase activity
V	0070847	cellular_component	core mediator complex
X	0016592	cellular_component	mediator complex
Z	0003712	molecular_function	transcription coregulator activity
Z	0006355	biological_process	regulation of DNA-templated transcription
Z	0016592	cellular_component	mediator complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9NPJ6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Region: {"description":"Interaction with the Elongin BC complex","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	95
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	39
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	42
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	41
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9BUE0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 1"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 3"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 4"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 5"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6P2C8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"Q6P2C8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)