6W1S

Atomic model of the mammalian Mediator complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003712	molecular_function	transcription coregulator activity
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016592	cellular_component	mediator complex
C	0000151	cellular_component	ubiquitin ligase complex
C	0001223	molecular_function	transcription coactivator binding
C	0003677	molecular_function	DNA binding
C	0003712	molecular_function	transcription coregulator activity
C	0003713	molecular_function	transcription coactivator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016567	biological_process	protein ubiquitination
C	0016592	cellular_component	mediator complex
C	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
C	0035019	biological_process	somatic stem cell population maintenance
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051123	biological_process	RNA polymerase II preinitiation complex assembly
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0070847	cellular_component	core mediator complex
D	0003712	molecular_function	transcription coregulator activity
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016592	cellular_component	mediator complex
E	0003712	molecular_function	transcription coregulator activity
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0016592	cellular_component	mediator complex
F	0003712	molecular_function	transcription coregulator activity
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0016592	cellular_component	mediator complex
G	0003712	molecular_function	transcription coregulator activity
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0016592	cellular_component	mediator complex
H	0003712	molecular_function	transcription coregulator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0016592	cellular_component	mediator complex
H	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
H	0051123	biological_process	RNA polymerase II preinitiation complex assembly
H	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
H	0070847	cellular_component	core mediator complex
I	0003712	molecular_function	transcription coregulator activity
I	0003713	molecular_function	transcription coactivator activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0016592	cellular_component	mediator complex
I	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
I	0032991	cellular_component	protein-containing complex
I	0035019	biological_process	somatic stem cell population maintenance
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0051123	biological_process	RNA polymerase II preinitiation complex assembly
I	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
I	0070847	cellular_component	core mediator complex
K	0003713	molecular_function	transcription coactivator activity
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0006366	biological_process	transcription by RNA polymerase II
K	0016592	cellular_component	mediator complex
K	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0046966	molecular_function	nuclear thyroid hormone receptor binding
K	0051123	biological_process	RNA polymerase II preinitiation complex assembly
K	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
K	0070847	cellular_component	core mediator complex
L	0000151	cellular_component	ubiquitin ligase complex
L	0003712	molecular_function	transcription coregulator activity
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005667	cellular_component	transcription regulator complex
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0016567	biological_process	protein ubiquitination
L	0016592	cellular_component	mediator complex
L	0030374	molecular_function	nuclear receptor coactivator activity
L	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
L	0035019	biological_process	somatic stem cell population maintenance
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046966	molecular_function	nuclear thyroid hormone receptor binding
L	0051123	biological_process	RNA polymerase II preinitiation complex assembly
L	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0070847	cellular_component	core mediator complex
M	0000151	cellular_component	ubiquitin ligase complex
M	0003712	molecular_function	transcription coregulator activity
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0016567	biological_process	protein ubiquitination
M	0016592	cellular_component	mediator complex
M	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
M	0051123	biological_process	RNA polymerase II preinitiation complex assembly
M	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
M	0061630	molecular_function	ubiquitin protein ligase activity
M	0070847	cellular_component	core mediator complex
N	0003712	molecular_function	transcription coregulator activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0016592	cellular_component	mediator complex
N	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
N	0051123	biological_process	RNA polymerase II preinitiation complex assembly
N	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
N	0070847	cellular_component	core mediator complex
O	0003712	molecular_function	transcription coregulator activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0016592	cellular_component	mediator complex
O	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
O	0032991	cellular_component	protein-containing complex
O	0035914	biological_process	skeletal muscle cell differentiation
O	0051123	biological_process	RNA polymerase II preinitiation complex assembly
O	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
O	0070847	cellular_component	core mediator complex
P	0016592	cellular_component	mediator complex
Q	0003712	molecular_function	transcription coregulator activity
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0016592	cellular_component	mediator complex
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005667	cellular_component	transcription regulator complex
R	0006355	biological_process	regulation of DNA-templated transcription
R	0010628	biological_process	positive regulation of gene expression
R	0016592	cellular_component	mediator complex
R	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
R	0051123	biological_process	RNA polymerase II preinitiation complex assembly
R	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
R	0070847	cellular_component	core mediator complex
R	2000409	biological_process	positive regulation of T cell extravasation
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0006366	biological_process	transcription by RNA polymerase II
S	0016592	cellular_component	mediator complex
S	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
S	0035019	biological_process	somatic stem cell population maintenance
S	0051123	biological_process	RNA polymerase II preinitiation complex assembly
S	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
S	0070847	cellular_component	core mediator complex
V	0000151	cellular_component	ubiquitin ligase complex
V	0003713	molecular_function	transcription coactivator activity
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005667	cellular_component	transcription regulator complex
V	0005730	cellular_component	nucleolus
V	0005829	cellular_component	cytosol
V	0006357	biological_process	regulation of transcription by RNA polymerase II
V	0016567	biological_process	protein ubiquitination
V	0016592	cellular_component	mediator complex
V	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
V	0035019	biological_process	somatic stem cell population maintenance
V	0051123	biological_process	RNA polymerase II preinitiation complex assembly
V	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
V	0061630	molecular_function	ubiquitin protein ligase activity
V	0070847	cellular_component	core mediator complex
X	0016592	cellular_component	mediator complex
Z	0003712	molecular_function	transcription coregulator activity
Z	0006355	biological_process	regulation of DNA-templated transcription
Z	0016592	cellular_component	mediator complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9NWA0

Chain	Residue	Details
F	SER106
C	LYS241

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:O75586

Chain	Residue	Details
C	LYS208
I	SER1124
I	SER1133
I	SER1141
I	SER1149

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