6VZS
Engineered TTLL6 mutant bound to gamma-elongation analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tubulin polyglutamylase TTLL6 | polymer | 453 | 53345.4 | 4 | UniProt (A4Q9E8) Pfam (PF03133) | Mus musculus (Mouse) | Tubulin--tyrosine ligase-like protein 6 |
| 2 | BA, E, S, WA (C, A, B, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 4 | Chemie (ADP) | |||
| 3 | CA, F, T, XA (C, A, B, D) | (2~{S})-2-[[[(3~{R})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid | non-polymer | 433.2 | 4 | Chemie (S3A) | |||
| 4 | AA, DA, EA, FA, G... (C, A, B, D) | GLYCEROL | non-polymer | 92.1 | 33 | Chemie (GOL) | |||
| 5 | AB, Q, R, UA, VA... (D, A, C, B) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 6 | BB, CB, DB, EB (A, B, C, D) | water | water | 18.0 | 212 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 51 - 503 (UniProt: A4Q9E8)
| PDB | External Database | Details |
|---|---|---|
| Ala 179 | Cys 179 | engineered mutation |
| Arg 180 | Gln 180 | engineered mutation |
| Ile 362 | His 362 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 213381.6 | |
| Non-Polymers* | Number of molecules | 49 |
| Total formula weight | 6675.3 | |
| All* | Total formula weight | 220056.9 |
