6VVO
Structure of the human clamp loader (Replication Factor C, RFC) bound to the sliding clamp (Proliferating Cell Nuclear Antigen, PCNA)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Replication factor C subunit 1 | polymer | 595 | 66221.2 | 1 | UniProt (P35251) Pfam (PF00004) Pfam (PF08519) | Homo sapiens (Human) | Activator 1 140 kDa subunit,A1 140 kDa subunit,Activator 1 large subunit,Activator 1 subunit 1,DNA-binding protein PO-GA,Replication factor C 140 kDa subunit,RFC140,Replication factor C large subunit |
| 2 | B (B) | Replication factor C subunit 2 | polymer | 354 | 39203.2 | 1 | UniProt (P35250) Pfam (PF00004) Pfam (PF08542) | Homo sapiens (Human) | Activator 1 40 kDa subunit,A1 40 kDa subunit,Activator 1 subunit 2,Replication factor C 40 kDa subunit,RFC40 |
| 3 | C (C) | Replication factor C subunit 5 | polymer | 340 | 38545.5 | 1 | UniProt (P40937) Pfam (PF00004) Pfam (PF21960) Pfam (PF08542) | Homo sapiens (Human) | Activator 1 36 kDa subunit,A1 36 kDa subunit,Activator 1 subunit 5,Replication factor C 36 kDa subunit,RFC36 |
| 4 | D (D) | Replication factor C subunit 4 | polymer | 363 | 39751.7 | 1 | UniProt (P35249) Pfam (PF08542) Pfam (PF00004) Pfam (PF21960) | Homo sapiens (Human) | Activator 1 37 kDa subunit,A1 37 kDa subunit,Activator 1 subunit 4,Replication factor C 37 kDa subunit,RFC37 |
| 5 | E (E) | Replication factor C subunit 3 | polymer | 356 | 40614.3 | 1 | UniProt (P40938) Pfam (PF13177) Pfam (PF21960) Pfam (PF22534) | Homo sapiens (Human) | Activator 1 38 kDa subunit,A1 38 kDa subunit,Activator 1 subunit 3,Replication factor C 38 kDa subunit,RFC38 |
| 6 | F, G, H (F, G, H) | Proliferating cell nuclear antigen | polymer | 261 | 28795.8 | 3 | UniProt (P12004) Pfam (PF00705) Pfam (PF02747) | Homo sapiens (Human) | PCNA,Cyclin |
| 7 | I, K, M, O (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 8 | J, L, N, P (A, B, C, D) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 4 | Chemie (AGS) | |||
| 9 | Q (E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence modifications
A: 556 - 1148 (UniProt: P35251)
D: 1 - 363 (UniProt: P35249)
| PDB | External Database | Details |
|---|---|---|
| Met 554 | - | expression tag |
| Asp 555 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 71 | Leu 71 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 310723.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2617.4 | |
| All* | Total formula weight | 313340.6 |
