6VR5

Complex of HLA-A2, a class I MHC, with a p53 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, D)	MHC class I antigen	polymer	293	33912.5	2	UniProt (Q861F7) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (A0A140T913)	Homo sapiens (Human)
2	B, D (B, E)	Beta-2-microglobulin	polymer	100	11879.4	2	UniProt (P61769) Pfam (PF07654)	Homo sapiens (Human)
3	E, F (P, Q)	Cellular tumor antigen p53 peptide	polymer	9	1114.3	2	UniProt (P04637)	Homo sapiens (Human)	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
4	G, H, I, J, K... (A, B, D, E, P...)	water	water		18.0	243	Chemie (HOH)

Sequence modifications

A, D: 1 - 275 (UniProt: Q861F7)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 276	-	expression tag
Gly 277	-	expression tag
Gly 278	-	expression tag
Leu 279	-	expression tag
Asn 280	-	expression tag
Asp 281	-	expression tag
Ile 282	-	expression tag
Phe 283	-	expression tag
Glu 284	-	expression tag
Ala 285	-	expression tag
Gln 286	-	expression tag
Lys 287	-	expression tag
Ile 288	-	expression tag
Glu 289	-	expression tag
Trp 290	-	expression tag
His 291	-	expression tag
Glu 292	-	expression tag

B, E: 2 - 100 (UniProt: P61769)

PDB	External Database	Details
Met 1	-	initiating methionine

P, Q: 1 - 9 (UniProt: P04637)

PDB	External Database	Details
His 8	Arg 175	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	93812.3
All*	Total formula weight	93812.3

*Water molecules are not included.