6VKA
HIV Integrase Core domain (IN) in complex with dimer-spanning ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Integrase | polymer | 165 | 18001.4 | 2 | UniProt (F2WR39) Pfam (PF00665) | Human immunodeficiency virus 1 (HIV-1) | |
| 2 | C, D, K, L, M... (A, B) | IODIDE ION | non-polymer | 126.9 | 6 | Chemie (IOD) | |||
| 3 | E (A) | 2,2'-{ethane-1,2-diylbis[oxyethane-2,1-diylcarbamoyl-4,1-phenyleneethyne-2,1-diyl(5-methyl-1-benzofuran-2,3-diyl)]}diacetic acid | non-polymer | 780.8 | 1 | Chemie (QZV) | |||
| 4 | F, G, H, I, J... (A, B) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 5 | T, U (A, B) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A, B: 50 - 212 (UniProt: F2WR39)
| PDB | External Database | Details |
|---|---|---|
| Gly 48 | - | expression tag |
| Ser 49 | - | expression tag |
| Glu 53 | Gln 53 | engineered mutation |
| Ser 56 | Cys 56 | engineered mutation |
| Glu 131 | Trp 131 | engineered mutation |
| Lys 185 | Phe 185 | engineered mutation |
| Glu 209 | Gln 209 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36002.8 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2502.9 | |
| All* | Total formula weight | 38505.7 |
