6VJA

Structure of CD20 in complex with rituximab Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, D	B-lymphocyte antigen CD20	polymer	278	31320.8	2	UniProt (P11836) Pfam (PF04103) In PDB	Homo sapiens (Human)	B-lymphocyte surface antigen B1,Bp35,Leukocyte surface antigen Leu-16,Membrane-spanning 4-domains subfamily A member 1
2	H, I	Rituximab Fab heavy chain	polymer	224	23733.5	2		Homo sapiens
3	L, M	Rituximab Fab light chain	polymer	213	23078.6	2		Homo sapiens
4	C, D	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	6	Chemie (Y01)

Sequence modifications

C, D: 41 - 297 (UniProt: P11836)

PDB	External Database	Details
Met 38	-	initiating methionine
Gly 39	-	expression tag
Ser 40	-	expression tag
Gly 298	-	expression tag
Asn 299	-	expression tag
Ser 300	-	expression tag
Glu 301	-	expression tag
Asn 302	-	expression tag
Leu 303	-	expression tag
Tyr 304	-	expression tag
Phe 305	-	expression tag
Gln 306	-	expression tag
Gly 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	156265.9
Non-Polymers*	Number of molecules	6
	Total formula weight	2920.4
All*	Total formula weight	159186.3

*Water molecules are not included.